Jacobsson M, Jönsson A, Albrektsson T, Turesson I
Int J Radiat Oncol Biol Phys. 1985 Nov;11(11):1963-9. doi: 10.1016/0360-3016(85)90278-0.
The Bone Growth Chamber (BGC) methodology was used to establish a dose-response relationship for regeneration of mature bone tissue after irradiation of 5, 8, 11, 15 and 25 Gy single dose 60Co. The BGC, which is a titanium implant, was inserted in the proximal tibial metaphyses, bilaterally, of a rabbit immediately following local irradiation to one tibia. Each animal thus served as its own control. During a healing period of 4 weeks, the two canals penetrating the implant became filled with more or less newly formed bone. At the end of the healing period, the implants were removed and taken apart and the newly formed bone was collected and its volume measured by microradiography and microdensitometry. It was found that in the dose range of 5 to 8 Gy bone regeneration was reduced by about 20% as compared to non-irradiated controls. Between 8 and 11 Gy, there was a critical range in that a small increase in dose resulted in a greatly reduced bone formation. At 11 Gy and above, the depression in bone formation, as compared to non-irradiated controls, was about 65 to 75%.
采用骨生长室（BGC）方法，对5、8、11、15和25 Gy单次剂量60Co照射后成熟骨组织的再生建立剂量反应关系。BGC是一种钛植入物，在对一侧胫骨进行局部照射后，立即双侧插入兔胫骨近端干骺端。因此，每只动物都作为自身对照。在4周的愈合期内，穿透植入物的两条管道或多或少地被新形成的骨组织填充。愈合期结束时，取出植入物并拆开，收集新形成的骨组织，通过显微放射照相术和显微密度测定法测量其体积。结果发现，在5至8 Gy的剂量范围内，与未照射的对照相比，骨再生减少了约20%。在8至11 Gy之间，存在一个临界范围，即剂量的小幅增加会导致骨形成大幅减少。在11 Gy及以上，与未照射的对照相比，骨形成的抑制约为65%至75%。
