Jacobsson M, Kälebo P, Albrektsson T, Turesson I
Acta Radiol Oncol. 1986 Jan-Feb;25(1):57-62. doi: 10.3109/02841868609136379.
A titanium implant, the bone harvest chamber (BHC), was used to investigate the regenerative capacity of mature bone after irradiation. One BHC was inserted in each proximal tibial metaphysis of a rabbit. One of these implant sites was irradiated (60Co single dose) to either 15 or 25 Gy while the other served as control. Newly formed bone grew through a canal that penetrated the implant. This newly formed bone was harvested from the implant every three weeks following irradiation and then quantified by microradiography and computer-assisted densitometry. In this way a ratio between bone formed on the irradiated side in comparison with the control could be established. An immediate depression in bone formation compared with the non-irradiated controls, was seen at both dose levels. A recovery in bone regenerative capacity was seen at 15 weeks after 15 Gy while the decrease in bone formation remained constant after 25 Gy during the 30 week follow-up period.
使用一种钛植入物——骨采集腔室（BHC）来研究成熟骨在辐照后的再生能力。在每只兔子的胫骨近端干骺端各插入一个BHC。其中一个植入部位接受15或25 Gy的辐照（60Co单次剂量），另一个作为对照。新形成的骨通过穿透植入物的管道生长。辐照后每三周从植入物中采集新形成的骨，然后通过显微放射照相术和计算机辅助密度测定法进行定量。通过这种方式，可以确定辐照侧与对照侧形成的骨之间的比例。与未辐照的对照相比，在两个剂量水平下均观察到骨形成立即受到抑制。在接受15 Gy辐照后15周时，骨再生能力出现恢复，而在25 Gy辐照后，在30周的随访期内骨形成的减少保持不变。
