Li Boling, Zhu Jingjing, Zhang Beng, Ling Zhenzhen, Zhao Yonglie, Leng Wendiao, Zhang Qinhong, Zhou Xiaoqing
Department of Acupuncture and Moxibustion, Beijing University of Chinese Medicine Affiliated Shenzhen Hospital, Shenzhen, 518000, People's Republic of China.
Department of Neurology, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450000, People's Republic of China.
Neuropsychiatr Dis Treat. 2025 Sep 10;21:2001-2016. doi: 10.2147/NDT.S543465. eCollection 2025.
To investigate the medication principles of Traditional Chinese Medicine (TCM) in the treatment of tic disorders (TD) and to provide evidence-based references for clinical practice.
A comprehensive search was conducted for literature on the treatment of TD using TCM from CNKI, Wan Fang Data, VIP, and PubMed. Based on the inclusion and exclusion criteria, TCM prescriptions were extracted and entered into an Excel 2020 database. Statistical analyses, including frequency analysis, association rule mining, and hierarchical clustering, were performed using Excel 2020, SPSS Modeler 18.0, and SPSS Statistics 26.0 software.
Totally 559 articles were included, comprising 1001 prescriptions, 369 herbs, and 13,678 frequencies. The properties of the herbs were primarily cold, warm, and mild, with the most common flavors being sweet, bitter, and pungent. The most frequent meridians were the liver, lung, and spleen. High-frequency herbs included Radix paeonia alba, Uncaria rhynchophylla, and Glycyrrhiza, etc. The primary efficacy included liver-soothing and wind-calming, tonifying spleen and Qi, and resuscitation-inducing aromatic, etc. The most frequent herb pairs were Uncaria rhynchophylla-Radix paeonia alba, Uncaria rhynchophylla-Glycyrrhiza, Radix paeonia alba-Glycyrrhiza, and Uncaria rhynchophylla-Glycyrrhiza-Radix paeonia alba, Radix paeonia alba-Gastrodia elata-Uncaria rhynchophylla. Forty herbs had a frequency of >100, which could be classified into 6 clusters: (1) hepatotropic and neuroregulatory herbs; (2) tonifying herbs; (3) hydragogue and dampness-regulating herbs, etc. Additionally, there were specific herb combinations such as Bupleurum chinense for liver-soothing, insect herbs for wind-expelling and meridian-unblocking, and Angelica sinensis and Ligusticum wallichii for removing blood stasis.
This study highlights the key medication principles and herb combinations used in the treatment of TD with TCM, providing valuable insights into current treatment practices. Further research, including standardized clinical assessments and investigation into the mechanisms of these herbs and their combinations, is needed to validate and optimize their potential therapeutic effects.
探讨中医治疗抽动障碍（TD）的用药规律，为临床实践提供循证参考。
全面检索中国知网、万方数据、维普资讯和PubMed中关于中医治疗TD的文献。根据纳入和排除标准，提取中医方剂并录入Excel 2020数据库。使用Excel 2020、SPSS Modeler 18.0和SPSS Statistics 26.0软件进行统计分析，包括频数分析、关联规则挖掘和层次聚类。
共纳入559篇文章，包含1001首方剂、369味中药及13678频次。中药药性以寒、温、平为主，药味以甘、苦、辛最为常见。归经以肝、肺、脾经最为多见。高频中药包括白芍、钩藤、甘草等。主要功效包括疏肝平肝、健脾益气、芳香开窍等。高频药对有钩藤-白芍、钩藤-甘草、白芍-甘草、钩藤-甘草-白芍、白芍-天麻-钩藤。频次>100的中药有40味，可分为6类：（1）疏肝及调节神经类中药；（2）补益类中药；（3）利水渗湿类中药等。此外，还有一些特定的中药组合，如疏肝的柴胡、祛风通络的虫类药、活血化瘀的当归和川芎。
本研究突出了中医治疗TD的关键用药规律和中药组合，为当前治疗实践提供了有价值的见解。需要进一步开展研究，包括标准化临床评估以及对这些中药及其组合作用机制的研究，以验证并优化其潜在治疗效果。
