Department of Chemical Engineering, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea.
Department of Chemical Engineering, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea.
J Control Release. 2022 Jan;341:132-146. doi: 10.1016/j.jconrel.2021.11.025. Epub 2021 Nov 20.
Transdermal delivery has proven to be one of the most favorable methods among novel drug delivery systems. Since drugs administered by transdermal delivery systems avoid the gastrointestinal tract, and thus avoid conversion by the liver, the likelihood of liver dysfunction and gastrointestinal tract irritation as side effects is low. Drug delivery through the skin has other advantages, such as maintaining an effective rate of drug delivery over time, a steady rate of circulation, and the benefits of a passive delivery system and diffusion. Transdermal drug delivery is achieved using patches which consist of different and specific layers. In the last few decades, many types of patches have been approved worldwide, such as medical plasters, which have been generally applied to the skin for localized diseases. Such patches can be traced back to ancient China (around 2000 BCE) and are the early precursors of today's transdermal patches. With the help of effective design, materials, manufacturing, and evaluation, a large number of drugs can now be administered using this valuable advanced technology. This study reviews different types of polymer patches, their advantages and disadvantages, and different studies related to transdermal drug delivery methods, and the advantages and disadvantages of each method. Different mechanisms of transdermal drug delivery system with patches are also discussed.
经皮给药系统已被证明是新型药物传递系统中最有利的方法之一。由于经皮给药系统给予的药物绕过胃肠道，从而避免肝脏的转化，因此肝功能障碍和胃肠道刺激等副作用的可能性较低。药物通过皮肤传递具有其他优点，例如随着时间的推移维持有效的药物传递率、稳定的循环率，以及被动传递系统和扩散的益处。经皮药物传递是通过贴剂来实现的，贴剂由不同的特定层组成。在过去的几十年中，全世界已经批准了许多类型的贴剂，例如医用膏药，它们通常用于治疗局部疾病。这些贴剂可以追溯到中国古代（公元前 2000 年左右），是当今经皮贴剂的早期前身。借助有效的设计、材料、制造和评估，现在可以使用这项有价值的先进技术来管理大量药物。本研究综述了不同类型的聚合物贴剂、它们的优缺点，以及与经皮药物传递方法相关的不同研究，以及每种方法的优缺点。还讨论了不同的经皮药物传递系统贴剂的不同机制。
