McCluey Ellie, Toubasi Ahmad A, Wang Jiacheng, Kazimuddin Habeeb F, Vinarsky Taegan, Gheen Caroline, Koch Carynn, Rohm Zachery, Hernandez Bryan, Clarke Margareta A, Cheek Rachael, Khalili Rozita, Jin Chaoyang, Lim Victoria, Kramer John, Xu Junzhong, Oguz Ipek, Bagnato Francesca
Neuroimaging Unit, Neuroimmunology Division, Department of Neurology, Vanderbilt University Medical Center (VUMC), Nashville, Tennessee, USA.
Vanderbilt University (VU) College of Arts and Science, Nashville, Tennessee, USA.
Ann Clin Transl Neurol. 2025 Sep 16. doi: 10.1002/acn3.70101.
The relationship between paramagnetic rim lesions (PRLs) and surrounding normally appearing white matter (NAWM) disease, potentially contributory to the associations seen between PRLs and clinical impairment, is underexplored.
To assess whether PRLs correlate with a greater degree of NAWM injury in early MS.
PRLs were identified on susceptibility weighted imaging (SWI) of 68 newly diagnosed patients. Each PRL was paired with an anatomically matched contralateral non-PRL (nPRL) from the same participant. Quantitative magnetization transfer imaging derived macromolecular-to-free pool-size ratio (PSR) and relaxation rate of the free water pool (R) values were extracted and compared between PRLs and nPRLs, NAWM surrounding PRLs and nPRLs, and whole brain WM lesions and NAWM of PRL+ and PRL- people with MS (pwMS).
PSR and R (p ≤ 0.028) values were lower in PRLs compared to nPRLs, but there were no differences in PSR and R (p ≥ 0.824) values between peri-PRLs and peri-nPRLs NAWM ROIs. PRL+ pwMS had similar PSR and R (p ≥ 0.267) of the whole brain NAWM, similar WM lesions PSR (p = 0.764) but lower R (p = 0.030) values.
In the early stages of MS, there is no association between PRLs and surrounding NAWM degree of injury.
顺磁性边缘病变（PRL）与周围正常外观白质（NAWM）疾病之间的关系尚未得到充分研究，而这种关系可能是PRL与临床损伤之间关联的原因。
评估PRL是否与早期多发性硬化症（MS）中更严重的NAWM损伤相关。
对68例新诊断患者的磁敏感加权成像（SWI）进行PRL识别。每个PRL与同一参与者解剖学上匹配的对侧非PRL（nPRL）配对。提取定量磁化传递成像得出的大分子与自由池大小比（PSR）和自由水池弛豫率（R）值，并在PRL与nPRL、PRL和nPRL周围的NAWM、PRL阳性和PRL阴性MS患者（pwMS）的全脑白质病变和NAWM之间进行比较。
与nPRL相比，PRL中的PSR和R（p≤0.028）值较低，但PRL周围和nPRL周围NAWM ROI之间的PSR和R（p≥0.824）值没有差异。PRL阳性pwMS的全脑NAWM的PSR和R（p≥0.267）相似，白质病变PSR（p = 0.764）相似，但R（p = 0.030）值较低。
在MS的早期阶段，PRL与周围NAWM损伤程度之间没有关联。
