Mora F, Quesada T, Pena J, Osorio C, Shaw S G
Clin Chim Acta. 1977 Oct 1;80(1):55-9. doi: 10.1016/0009-8981(77)90263-7.
The concentrations of nine proteins, alpha-1-acid glycoprotein, antitrypsin, prealbumin, transferrin, albumin, IgG, ceruloplasmin, IgA and alpha-2-macroglobulin, have been determined in the serum and CSF of two groups of patients, one control and one experimental, by an immunological method. The experimental group were patients suffering from grand mal epilepsy. The control group showed no detectable neurological disorder. In the group of grand mal epileptics, only prealbumin showed a significant elevation in CSF when compared with the control group. In contrast, the rest of the proteins are decreased with respect to the controls except for alpha 1-acid glycoprotein and transferrin. The results from this study also suggest that something more than an ultrafiltration process dependent upon molecular weight, is important in determining the concentration of some serum proteins in the CSF.
通过免疫学方法测定了两组患者（一组为对照组，一组为实验组）血清和脑脊液中九种蛋白质的浓度，这九种蛋白质分别是α-1-酸性糖蛋白、抗胰蛋白酶、前白蛋白、转铁蛋白、白蛋白、免疫球蛋白G、铜蓝蛋白、免疫球蛋白A和α-2-巨球蛋白。实验组为癫痫大发作患者，对照组未发现可检测到的神经疾病。在癫痫大发作患者组中，与对照组相比，仅脑脊液中的前白蛋白显著升高。相反，除α-1-酸性糖蛋白和转铁蛋白外，其余蛋白质相对于对照组均有所降低。该研究结果还表明，在决定脑脊液中某些血清蛋白浓度时，除了依赖分子量的超滤过程外，还有其他因素起着重要作用。
