Elovaara I, Icén A, Palo J, Erkinjuntti T
J Neurol Sci. 1985 Aug;70(1):73-80. doi: 10.1016/0022-510x(85)90189-3.
Serum and cerebrospinal fluid (CSF) from 22 ambulatory and 10 institutionalised patients with Alzheimer's disease (AD) and 22 age-matched controls were assayed nephelometrically for concentrations of IgG, IgA, IgM, haptoglobin, transferrin, prealbumin and albumin. The CSF/serum ratio and index were calculated for each protein. In the CSF of ambulatory patients IgG, transferrin and albumin were elevated while the institutionalised patients had higher IgG and IgA levels compared to the controls. The CSF haptoglobin was elevated in institutionalised AD patients compared to those who were ambulatory. The CSF/serum ratio for albumin was elevated in both groups. An increase in the IgG ratio was also found in both groups. The ratios for haptoglobin and prealbumin were markedly increased in the institutionalised patients. CSF indices gave no evidence for increased intrathecal synthesis of any of the proteins investigated. The increased CSF/serum ratios for IgG and albumin and also the higher CSF albumin in patients with AD suggest an increased blood-brain barrier permeability in this disease. The high prealbumin ratio may be related to amyloidogenesis often present in AD.
对22名门诊和10名住院的阿尔茨海默病（AD）患者以及22名年龄匹配的对照者的血清和脑脊液（CSF）进行比浊法检测，以测定IgG、IgA、IgM、触珠蛋白、转铁蛋白、前白蛋白和白蛋白的浓度。计算每种蛋白质的脑脊液/血清比值和指数。在门诊患者的脑脊液中，IgG、转铁蛋白和白蛋白升高，而住院患者的IgG和IgA水平高于对照组。与门诊患者相比，住院AD患者的脑脊液触珠蛋白升高。两组患者的脑脊液白蛋白脑脊液/血清比值均升高。两组患者的IgG比值也有所增加。住院患者的触珠蛋白和前白蛋白比值显著增加。脑脊液指数没有显示所研究的任何蛋白质的鞘内合成增加。AD患者脑脊液/血清中IgG和白蛋白比值的增加以及脑脊液白蛋白的升高表明该疾病中血脑屏障通透性增加。高前白蛋白比值可能与AD中常见的淀粉样蛋白生成有关。
