Bradley-Moore A M, Greenwood B M, Bradley A K, Akintunde A, Attai E D, Fleming A F, Bartlett A, Bidwell D E, Voller A, Kirkwood B R
Trans R Soc Trop Med Hyg. 1985;79(5):722-7. doi: 10.1016/0035-9203(85)90203-2.
The efficacy of chloroquine and pyrimethamine as malaria chemoprophylactics was investigated in young Nigerian children. Chloroquine resistance had not been documented in the study area; pyrimethamine resistance was probably present but uncommon. Children who received weekly chemoprophylaxis with pyrimethamine had a lower prevalence of malaria parasitaemia and malaria antibodies than children who received weekly chemoprophylaxis with chloroquine. Pyrimethamine given monthly gave a comparable degree of protection to chloroquine given weekly. Chloroquine frequently induced vomiting in young children and this may have impaired its efficacy as a prophylactic. We conclude that, in an area where neither chloroquine nor pyrimethamine resistance is prevalent, pyrimethamine is a better chemoprophylactic for young children than chloroquine.
在尼日利亚幼儿中研究了氯喹和乙胺嘧啶作为疟疾化学预防药物的疗效。研究地区尚未记录到氯喹耐药性；乙胺嘧啶耐药性可能存在但不常见。与接受每周一次氯喹化学预防的儿童相比，接受每周一次乙胺嘧啶化学预防的儿童疟疾寄生虫血症和疟疾抗体的患病率较低。每月服用乙胺嘧啶提供的保护程度与每周服用氯喹相当。氯喹经常导致幼儿呕吐，这可能会削弱其作为预防药物的疗效。我们得出结论，在氯喹和乙胺嘧啶耐药性均不普遍的地区，对于幼儿来说，乙胺嘧啶是比氯喹更好的化学预防药物。
