Bradley-Moore A M, Greenwood B M, Bradley A K, Bartlett A, Bidwell D E, Voller A, Kirkwood B R, Gilles H M
Ann Trop Med Parasitol. 1985 Dec;79(6):549-62. doi: 10.1080/00034983.1985.11811962.
One hundred and ninety-eight Nigerian children who received weekly chemoprophylaxis with chloroquine from shortly after birth until the age of one year or two years and 185 age-matched controls were studied. Chemoprophylaxis with chloroquine was partially, but not completely, effective in controlling malaria. Clinical malaria was documented significantly less frequently in protected children than in control children, and only 9% of random blood films obtained from protected children were positive for Plasmodium falciparum while 41% of random blood films from control children were positive for this parasite. Mean malaria antibody levels were lower in protected than in control children; for ELISA and precipitin antibodies the difference between the two groups was less marked at two years than at one year. Mortality was similar among protected and among control children. No rebound mortality or morbidity was observed after chemoprophylaxis was stopped.
对198名从出生后不久直至1岁或2岁每周接受氯喹化学预防的尼日利亚儿童以及185名年龄匹配的对照儿童进行了研究。氯喹化学预防在控制疟疾方面有一定效果，但并不完全有效。接受预防的儿童中临床疟疾的记录明显少于对照儿童，从接受预防的儿童中随机抽取的血片中只有9%恶性疟原虫呈阳性，而对照儿童随机血片中有41%该寄生虫呈阳性。接受预防的儿童的平均疟疾抗体水平低于对照儿童；对于ELISA和沉淀素抗体，两组之间的差异在2岁时比1岁时不那么明显。接受预防的儿童和对照儿童的死亡率相似。停止化学预防后未观察到死亡率或发病率的反弹。
