Wang Yi-Hao, Wang Limei, Ho Ping-Chih
Department of Oncology, University of Lausanne, Lausanne, Switzerland.
Ludwig Institute for Cancer Research, University of Lausanne, Épalinges, Switzerland.
EMBO J. 2025 Sep 16. doi: 10.1038/s44318-025-00569-z.
Cellular metabolism plays a pivotal role in regulating the effector functions and fate decisions of immune cells, shaping immune responses in homeostasis and disease. Metabolic pathways also serve as critical signaling hubs governing immune cell behavior. Deregulated metabolic pathways contribute to immune dysfunction, fueling disease progression and creating challenges for therapeutic interventions. The recent development of advanced technologies to delineate immunometabolic regulation has revolutionized our understanding of immune cell biology. These tools, ranging from quantitative single-cell metabolomics to in vivo spatial tissue profiling and DC-based metabolic therapy, have shifted the focus from broad nutrient pathways to a detailed exploration of metabolic reprogramming within disease microenvironments, revealing how metabolic changes drive immune cell activation, differentiation, and effector responses. The integration of immunometabolic insights into clinical practice holds strong potential for advancing precision medicine and developing targeted therapies that restore immune balance in pathological conditions. Here, we summarize emerging cutting-edge technologies related to immunometabolism and critically reflect on their current limitations. Finally, we discuss potential needs for developing novel methods that can uncover the intricate interplay between metabolism and immune cell function.
细胞代谢在调节免疫细胞的效应功能和命运决定中起着关键作用，在稳态和疾病中塑造免疫反应。代谢途径也是控制免疫细胞行为的关键信号枢纽。代谢途径失调会导致免疫功能障碍，加速疾病进展，并给治疗干预带来挑战。近年来，用于描绘免疫代谢调节的先进技术的发展彻底改变了我们对免疫细胞生物学的理解。这些工具，从定量单细胞代谢组学到体内空间组织分析以及基于树突状细胞的代谢疗法，已经将重点从广泛的营养途径转移到对疾病微环境中代谢重编程的详细探索，揭示了代谢变化如何驱动免疫细胞的激活、分化和效应反应。将免疫代谢见解整合到临床实践中，在推进精准医学和开发在病理条件下恢复免疫平衡的靶向疗法方面具有巨大潜力。在这里，我们总结了与免疫代谢相关
