Mohammed Rania Mamoun Ali, Yousif Shaza Mohammed, Marouf Ali A S
Sudan University of Science and Technology, Khartoum, Sudan.
Lasers Med Sci. 2025 Sep 17;40(1):362. doi: 10.1007/s10103-025-04634-1.
Unwanted hair growth can cause significant cosmetic and psychosocial distress, particularly in women with darker skin types, for whom safe and effective long-term hair reduction options are limited. This study aimed to evaluate the efficacy, safety, and patient satisfaction of 808 nm diode laser hair reduction in Sudanese women with Fitzpatrick skin types IV-VI, with a focus on documenting adverse effects.
In this prospective clinical study, ten Sudanese women with Fitzpatrick skin types IV-VI underwent three sessions of 808 nm diode laser hair reduction (20 W, 12 mm spot size, 8-9 J/cm² fluence, 36 ms pulse width, 1 Hz frequency) with integrated sapphire cooling. Treatments targeted the underarm (n = 6) and chin (n = 4) areas at three-week intervals. Efficacy was assessed by quantifying hair reduction, while safety was evaluated through systematic documentation of adverse effects. Patient satisfaction was measured using a 10-point Likert scale.
After three treatment sessions, the mean hair reduction was 57.9% (range 45.7-66.7%) in the underarm group and 56.7% (range 45.5-70.8%) in the chin group. Hair texture changed from coarse to fine, and skin at treated sites appeared smoother and lighter. Side effects were minimal and transient: one patient (skin type VI) reported pain during the first session, and one developed a mild, superficial blister at 9 J/cm², with no further complications after fluence adjustment. No cases of keloid formation, scarring, wound infection, prolonged erythema, purpura, or pigmentary changes were observed. All patients (100%) reported satisfaction with the treatment, attended all follow-up visits, and would recommend the procedure; 80% rated their results as excellent (> 6/10), and 20% as good (4-6/10).
The 808 nm diode laser is a safe and effective modality for hair reduction in Sudanese women with Fitzpatrick skin types IV-VI, producing high satisfaction and minimal side effects. These findings provide valuable evidence for the use of diode lasers in darker-skinned populations, who are traditionally at higher risk for laser-related complications. Further research with larger cohorts and longer follow-up is recommended to optimize treatment protocols.
毛发过多生长会导致严重的美容和心理困扰，尤其是对于肤色较深的女性，她们可选择的安全有效的长期减少毛发的方法有限。本研究旨在评估808纳米二极管激光脱毛对皮肤菲茨帕特里克分型为IV - VI型的苏丹女性的疗效、安全性及患者满意度，重点记录不良反应。
在这项前瞻性临床研究中，10名皮肤菲茨帕特里克分型为IV - VI型的苏丹女性接受了3次808纳米二极管激光脱毛治疗（功率20瓦，光斑大小12毫米，能量密度8 - 9焦耳/平方厘米，脉宽36毫秒，频率1赫兹），采用集成蓝宝石冷却技术。治疗部位为腋下（6例）和下巴（4例），每隔三周进行一次治疗。通过量化毛发减少情况评估疗效，通过系统记录不良反应评估安全性。使用10分制李克特量表测量患者满意度。
经过3次治疗后，腋下组平均毛发减少率为57.9%（范围45.7% - 66.7%），下巴组为56.7%（范围45.5% - 70.8%）。毛发质地从粗糙变为细软，治疗部位的皮肤看起来更光滑、颜色更浅。副作用轻微且短暂：1例（皮肤VI型）患者在第一次治疗时报告疼痛，1例在能量密度为9焦耳/平方厘米时出现轻度浅表水疱，调整能量密度后未出现进一步并发症。未观察到瘢痕疙瘩形成、瘢痕、伤口感染、持续性红斑、紫癜或色素沉着改变的病例。所有患者（100%）均表示对治疗满意，参加了所有随访，并会推荐该治疗方法；80%的患者将治疗效果评为优秀（> 6/10），20%评为良好（4 - 6/10）。
808纳米二极管激光是一种安全有效的脱毛方式，可用于皮肤菲茨帕特里克分型为IV - VI型的苏丹女性，患者满意度高且副作用极小。这些发现为在肤色较深人群中使用二极管激光提供了有价值的证据，这类人群传统上激光相关并发症风险较高。建议进行更大样本量和更长随访时间的进一步研究，以优化治疗方案。
