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单细胞多组学:洞察非编码转录组的窗口

Single-cell multi-omics as a window into the non-coding transcriptome.

作者信息

Chiu Hua-Sheng

机构信息

Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.

出版信息

Hereditas. 2025 Sep 16;162(1):179. doi: 10.1186/s41065-025-00573-7.

Abstract

This Editorial introduces my research background as the new Non-coding RNA Section Editor at Hereditas and serves as a call for submissions for the special collection, "Single-Cell Multi-Omic Analysis of Cancer Interactome". Single-cell multi-omic approaches are opening new windows into the non-coding transcriptome, revealing how these molecules shape cellular identity in ways bulk analyses often miss. In this article, I focus on non-coding RNAs and emphasize the importance of integrative systems biology and multi-omics in this field, while also highlighting how these perspectives can guide future discoveries. I cordially invite you to contribute your work by submitting manuscripts to this collection.

摘要

这篇社论介绍了我作为《遗传》杂志新的非编码RNA栏目编辑的研究背景,并呼吁大家为“癌症相互作用组的单细胞多组学分析”专题文集投稿。单细胞多组学方法为非编码转录组学打开了新的窗口,揭示了这些分子如何以整体分析常常遗漏的方式塑造细胞特性。在本文中,我聚焦于非编码RNA,强调综合系统生物学和多组学在该领域的重要性,同时也突出这些观点如何能够指导未来的发现。我诚挚地邀请大家通过向这个专题文集投稿来贡献你们的作品。

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