Wu Yunqin, Lai Zhenzhen, Li Ange, Han Weiwei, Liu Xiaoxia, Fan Weinv
Department of Neurology, Ningbo No. 2 Hospital, Ningbo, China.
Department of Neurology, Tiantai People's Hospital of Zhejiang Provine, Tiantai Branch of Zhejiang Provincial People's Hospital, Hangzhou Medical College, Taizhou, Zhejiang, China.
Front Neurol. 2025 Sep 1;16:1638357. doi: 10.3389/fneur.2025.1638357. eCollection 2025.
Growing evidence implicates vitamin D in inner ear homeostasis, though its association with Ménière's disease (MD) remains incompletely characterized. This study aimed to compare serum 25-hydroxyvitamin D (25(OH)D) levels between patients with MD and healthy controls and to assess its correlation with hearing thresholds in MD cohort.
In this cross-sectional study, 49 patients with MD and 250 matched healthy controls were enrolled at our institution between January 2023 and January 2025. Groups were matched for demographics, comorbidities, exercise habits, and seasonal blood collection timing. Serum 25(OH)D levels and pure-tone audiometry (PTA) results were measured and analyzed.
Patients with MD exhibited significantly lower 25(OH)D levels than controls [18.4 ± 5.9 (45.9 ± 14.7 nmol/L) vs. 21.1 ± 6.2 ng/mL (52.7 ± 15.5 nmol/L); = 0.006]. After adjusting for covariates, vitamin D deficiency was independently associated with MD (adjusted OR = 2.21; 95% CI: 1.13-4.32; = 0.021). A moderate inverse correlation existed between 25(OH)D and PTA thresholds ( = -0.440, = 0.002).
Hypovitaminosis D is associated with MD and hearing loss severity, warranting further longitudinal studies to explore causality and therapeutic implications.
越来越多的证据表明维生素D与内耳稳态有关，但其与梅尼埃病（MD）的关联仍未完全明确。本研究旨在比较MD患者与健康对照者的血清25-羟基维生素D（25(OH)D）水平，并评估其与MD队列中听力阈值的相关性。
在这项横断面研究中，2023年1月至2025年1月期间，在我们机构招募了49例MD患者和250例匹配的健康对照者。根据人口统计学、合并症、运动习惯和季节性采血时间对两组进行匹配。测量并分析血清25(OH)D水平和纯音听力测定（PTA）结果。
MD患者的25(OH)D水平显著低于对照组[18.4±5.9（45.9±14.7nmol/L）vs.21.1±6.2ng/mL（52.7±15.5nmol/L）；P=0.006]。在调整协变量后，维生素D缺乏与MD独立相关（调整后的OR=2.21；95%CI：1.13-4.32；P=0.021）。25(OH)D与PTA阈值之间存在中度负相关（P=-0.440，P=0.002）。
维生素D缺乏与MD及听力损失严重程度相关，需要进一步的纵向研究来探讨因果关系和治疗意义。
