Wu Huifen, Lu Baoquan, Xiang Nian, Qiu Min, Da Hui, Xiao Qiang, Zhang Yan, Shi Hui
Hubei Engineering University, Xiaogan, Hubei, China.
Huazhong University of Science and Technology, Wuhan, Hubei, China.
Front Psychol. 2025 Sep 1;16:1495821. doi: 10.3389/fpsyg.2025.1495821. eCollection 2025.
Previous studies have found that resilience is a protective factor against depression, and new antidepressant methods can be developed from the perspective of resilience. However, it remains unclear how resilience protects individuals from depressive symptoms and what neural mechanisms underlie this "protective" effect.
We recruited 237 participants in our study according to the depression and anxiety clinical scale (HADS) and Connor-Davidson Resilience Scale (CD-RISC), including 100 healthy controls (HADS≤7) and 137 depressed patients (HADS≥8). All participants were evaluated using 53-channel functional near-infrared spectroscopy (fNIRS) to detect cerebral hemodynamic differences during autobiographical memory tasks.
The results showed that (1) the activation of oxy-Hb in the left dorsolateral prefrontal cortex (DLPFC) was significantly higher in the positive emotional valence condition than in the negative emotional valence condition for the groups of depression-high resilience and healthy-low resilience, while there was no significant difference between the positive and negative emotional valences observed in response to for the groups of depression-low resilience and healthy-high resilience. (2) Oxy-Hb activation under positive emotional valence was significantly higher in the group with healthy-low resilience than healthy-high resilience and depression-low resilience. (3) Under the negative emotional valence condition, resilience mediated the indirect effect of depression on oxy-Hb activation in the left orbitofrontal cortex (OFC).
fNIRS may be a useful tool for diagnosing and characterizing depression in patients with high or low resilience and improving individual resilience may be a new perspective for diagnosing and intervening in depression.
以往研究发现心理韧性是预防抑郁症的保护因素，可从心理韧性角度开发新的抗抑郁方法。然而，心理韧性如何保护个体免受抑郁症状影响以及这种“保护”作用背后的神经机制仍不清楚。
我们根据抑郁和焦虑临床量表（HADS）及康纳 - 戴维森心理韧性量表（CD - RISC）招募了237名参与者，其中包括100名健康对照者（HADS≤7）和137名抑郁症患者（HADS≥8）。所有参与者均使用53通道功能近红外光谱技术（fNIRS）进行评估，以检测自传体记忆任务期间的脑血流动力学差异。
结果显示：（1）对于抑郁 - 高心理韧性组和健康 - 低心理韧性组，在积极情绪效价条件下左侧背外侧前额叶皮质（DLPFC）的氧合血红蛋白（oxy - Hb）激活显著高于消极情绪效价条件，而抑郁 - 低心理韧性组和健康 - 高心理韧性组在积极和消极情绪效价反应之间未观察到显著差异。（2）在积极情绪效价下，健康 - 低心理韧性组的oxy - Hb激活显著高于健康 - 高心理韧性组和抑郁 - 低心理韧性组。（3）在消极情绪效价条件下，心理韧性介导了抑郁对左侧眶额皮质（OFC）中oxy - Hb激活的间接效应。
fNIRS可能是诊断和表征高或低心理韧性患者抑郁症的有用工具，提高个体心理韧性可能是诊断和干预抑郁症的新视角。
