School of Education, Jianghan University, Wuhan, China.
School of Education Science, Huazhong University of Science and Technology, Wuhan, China.
J Affect Disord. 2023 Apr 1;326:216-224. doi: 10.1016/j.jad.2023.01.115. Epub 2023 Feb 1.
Previous studies have proved that there is a strong association between dorsolateral prefrontal cortex and mood symptoms. This study aimed at using functional near-infrared spectroscopy technology to invest brain activity in dlPFC of depressed individuals with and without suicidal ideation during emotional autobiographical memory test, and to understand their differences in brain cognitive mechanisms. It is helpful to improve our ability to predict and subsequently to prevent suicide.
85 young adults participated in the study by a simple random sampling method, with health control (34participants), depression with suicidal ideation (17participants), and depression without suicidal ideation (34participants). The average oxyhemoglobin in dlPFC of subjects during EAMT was collected by a 53-channel fNIRS imaging device.
A marginal significant difference was found between three groups in left dlPFC and right dlPFC. Post hoc analysis revealed that: (1) under negative emotion, depression without suicidal ideation group had higher activation than healthy control group in left dlPFC. (2) under positive emotion, depression with suicidal ideation group had lower activation than healthy control in right dlPFC.
Results indicated that the depressed individuals with suicidal ideation had some deficits in executive function in right dlPFC, while the depressed adults without suicidal ideation may have mechanism of resource compensatory recruitment in left dlPFC and the dlPFC abnormality involved in the pathophysiology, may localize within left hemisphere. The depressed individuals with and without suicidal ideation had the different mechanisms in dlPFC and fNIRS can be a neuroimaging biomarker characterizing or predicting suicidality in depressed individuals.
先前的研究已经证明背外侧前额叶皮层与情绪症状之间存在很强的关联。本研究旨在使用功能近红外光谱技术（fNIRS），在情绪自传体记忆测试中，研究有和无自杀意念的抑郁个体背外侧前额叶皮层（dlPFC）的脑活动，并了解他们在大脑认知机制上的差异。这有助于提高我们预测和随后预防自杀的能力。
采用简单随机抽样法，对 85 名年轻成年人进行研究，其中健康对照组（34 名参与者）、有自杀意念的抑郁症组（17 名参与者）和无自杀意念的抑郁症组（34 名参与者）。使用 53 通道近红外光谱成像仪收集受试者在 EAMT 期间 dlPFC 的平均氧合血红蛋白。
三组在左 dlPFC 和右 dlPFC 之间存在边缘显著差异。事后分析显示：（1）在负性情绪下，无自杀意念的抑郁组在左 dlPFC 的激活程度高于健康对照组；（2）在正性情绪下，有自杀意念的抑郁组在右 dlPFC 的激活程度低于健康对照组。
结果表明，有自杀意念的抑郁个体右 dlPFC 的执行功能存在一些缺陷，而无自杀意念的抑郁成年人可能在左 dlPFC 中存在资源补偿招募的机制，并且 dlPFC 异常可能参与发病机制，可能局限于左侧半球。有和无自杀意念的抑郁个体在 dlPFC 中存在不同的机制，fNIRS 可以作为一种神经影像学生物标志物，用于特征描述或预测抑郁个体的自杀倾向。
