Jack R S, Imanishi-Kari T, Rajewsky K
Eur J Immunol. 1977 Aug;7(8):559-65. doi: 10.1002/eji.1830070813.
Strain C57BL/6 mice produce a highly restricted primary response to the (4-hydroxy-3-nitrophenyl)acetyl (NP) group. This response is composed of molecules having mu or gamma1 heavy chains and light chains of the lambda type. A guinea pig anti-idiotype was raised to the purified C57BL/6 primary anti-NP immunoglobulin. After suitable absorption, this anti-idiotype was shown to detect markers present on the primary anti-NP immunoglobulin only of those strains which express the Ig-1b allotype. Breeding experiments demonstrated that the marker segregated with the heavy chain linkage group.
C57BL/6品系小鼠对（4-羟基-3-硝基苯基）乙酰（NP）基团产生高度受限的初次反应。这种反应由具有μ或γ1重链以及λ型轻链的分子组成。制备了一种豚鼠抗独特型抗体，用于纯化的C57BL/6初次抗NP免疫球蛋白。经过适当吸收后，该抗独特型抗体显示仅能检测那些表达Ig-1b同种异型的品系的初次抗NP免疫球蛋白上存在的标志物。育种实验表明，该标志物与重链连锁群分离。
