Stashenko P, Klinman N R
J Immunol. 1980 Aug;125(2):531-7.
The chain composition and fine specificity of the anti-(4-hydroxy-3-nitrophenyl) acetyl (NP) response was examined at the level of individual clones in BALB/c (Ig-1a allotype) and B10.D2 (Ig-1b) mice. The primary anti-NP serum response of B10.D2 is distinguished from that of BALB/c by its restricted heterogeneity and unusual heteroclitic fine specificity, which appear to be associated with antibodies bearing a unique allotype-linked idiotype(s) (NP-b) paired with lambda light (L) chains. At the clonal precursor level, the 10.d2 anti-NP primary response was found to be characterized by less diversity than that of BALB/c and is dominated by several clonotypes with the heteroclitic fine specificity. However, BALB/c also possess abundant heteroclitic precursors (53%), which are expressed but apparently obscured in its more heterogeneous serum response. Heteroclitic fine specificity in both strains is occasionally associated with clones bearing kappa as well as lambda L chains.
在BALB/c（Ig-1a同种异型）和B10.D2（Ig-1b）小鼠的单个克隆水平上，检测了抗（4-羟基-3-硝基苯基）乙酰（NP）反应的链组成和精细特异性。B10.D2的主要抗NP血清反应与BALB/c的不同，其具有有限的异质性和不寻常的偏侧性精细特异性，这似乎与带有独特的同种异型相关独特型（NP-b）并与λ轻（L）链配对的抗体有关。在克隆前体水平上，发现10.d2抗NP初次反应的特征是多样性低于BALB/c，并且由几种具有偏侧性精细特异性的克隆型主导。然而，BALB/c也拥有丰富的偏侧性前体（53%），这些前体在其更具异质性的血清反应中表达但显然被掩盖了。两种品系中的偏侧性精细特异性偶尔也与携带κ链以及λ L链的克隆相关。
