Woodward D F, Owen D A
Eur J Pharmacol. 1982 Jan 22;77(2-3):103-12. doi: 10.1016/0014-2999(82)90003-6.
The effect of mepyramine, cimetidine and a combination of both types of histamine receptor antagonist on the cutaneous vasodilatation, increased vascular permeability and oedema formation associated with UV injury was quantitatively evaluated. The specificity of the histamine antagonists employed in this study was verified by examining their effect on the vascular changes produced by selective H1- and H2-receptor agonists. The immediate, transient increase in vascular permeability and hyperaemia evoked by UV radiation was substantially reduced by a combination of mepyramine and cimetidine whereas the vascular changes which comprise the delayed, prolonged phase of the inflammatory response remained unaltered by histamine receptor blockade. It is concluded that histamine plays a major role in mediating the initial, transient phase of UV-induced inflammation but does not appear to be involved in mediating the subsequent sustained vascular changes.
对吡拉明、西咪替丁以及这两种组胺受体拮抗剂联用，针对与紫外线损伤相关的皮肤血管扩张、血管通透性增加和水肿形成的影响进行了定量评估。通过检测它们对选择性H1和H2受体激动剂所产生的血管变化的影响，验证了本研究中所使用的组胺拮抗剂的特异性。吡拉明与西咪替丁联用可显著减轻紫外线辐射引起的血管通透性和充血的即时、短暂增加，而组胺受体阻断对构成炎症反应延迟、持续阶段的血管变化没有影响。得出的结论是，组胺在介导紫外线诱导炎症的初始短暂阶段中起主要作用，但似乎不参与介导随后持续的血管变化。
