Bhattacharya S K, Das N
Agents Actions. 1985 Dec;17(2):150-2. doi: 10.1007/BF01966584.
Intracerebroventricularly (icv) administered histamine (5, 10 and 20 micrograms) produced a dose-related anti-inflammatory effect against carrageenin-induced pedal edema in rats. The effect of histamine was mimicked by the H1 receptor agonist, 2-methylhistamine, but not by the H2 receptor agonist, 4-methylhistamine. The anti-inflammatory effect of centrally administered histamine was antagonised by mepyramine, a H1 receptor antagonist, but not by cimetidine, a H2 receptor antagonist. The anti-inflammatory effect of icv histamine was inhibited in bilaterally adrenalectomised rats but was unaffected by peripheral chemical sympathectomy induced by 6-hydroxydopamine.
脑室内（icv）注射组胺（5、10和20微克）对角叉菜胶诱导的大鼠足爪水肿产生剂量相关的抗炎作用。组胺的作用可被H1受体激动剂2-甲基组胺模拟，但不能被H2受体激动剂4-甲基组胺模拟。中枢给予组胺的抗炎作用被H1受体拮抗剂美吡拉敏拮抗，但不被H2受体拮抗剂西咪替丁拮抗。双侧肾上腺切除的大鼠中，icv组胺的抗炎作用受到抑制，但不受6-羟基多巴胺诱导的外周化学交感神经切除术的影响。
