Zhang Fengrui, Tao Yan, Niu Junkun
Department of Gastroenterology The First Affiliated Hospital of Kunming Medical University Kunming Yunnan China.
Yunnan Province Clinical Research Center for Digestive Diseases Kunming Yunnan China.
JGH Open. 2025 Sep 16;9(9):e70279. doi: 10.1002/jgh3.70279. eCollection 2025 Sep.
Hookworms primarily parasitize in the intestinal tract, and the gastric involvement is extremely rare, which often leads to misdiagnosis. We present two cases of hookworm infection that mimicked early gastric carcinoma.
Two patients presented with clear boundaries gastric mucosa lesions exhibiting brownish discoloration, resembling early gastric mucosal cancer. Live hookworms were identified on the gastric mucosal surface using magnifying endoscopy combined with narrow-band imaging. Hookworm eggs were detected in both patients through fecal etiological evaluation. Following standard anthelmintic treatment, both the lesions and the worms resolved.
In the differential diagnosis of localized well-defined gastric mucosal lesions, parasitic infections should be considered in addition to neoplastic lesions. Magnifying endoscopy plays a critical role in distinguishing gastric mucosal lesions suspicious for parasitic infection.
钩虫主要寄生于肠道，累及胃部极为罕见，常导致误诊。我们报告两例酷似早期胃癌的钩虫感染病例。
两名患者均出现边界清晰的胃黏膜病变，呈褐色，类似早期胃黏膜癌。通过放大内镜联合窄带成像在胃黏膜表面发现活钩虫。通过粪便病原学评估在两名患者中均检测到钩虫卵。经过标准驱虫治疗后，病变和虫体均消失。
在鉴别诊断局限性边界清晰的胃黏膜病变时，除肿瘤性病变外，还应考虑寄生虫感染。放大内镜在鉴别可疑寄生虫感染的胃黏膜病变中起关键作用。
