Wu Kai, Li Qingyao, Wang Wei, Wang Lei, Wang Shuxia
Clinical Laboratory, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu, China.
Department of Radiology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Eur J Clin Microbiol Infect Dis. 2025 Sep 18. doi: 10.1007/s10096-025-05261-y.
Schaalia infections are uncommon, with Schaalia cardiffensis infections being exceptionally rare. A 66-year-old, penicillin-allergic female presented with fever, cough and purulent sputum. Chest computed tomography revealed bilateral pneumonia, right loculated empyema and right lower lobe atelectasis. Initial drainage cultures identified only Streptococcus oralis, but subsequent anaerobic enrichment and 16 S rRNA gene sequencing confirmed S. cardiffensis, an obligate anaerobe. Due to absent susceptibility data, we established initial antimicrobial susceptibility profile for S. cardiffensis. Successful management was achieved using alternative antibiotics combined with percutaneous drainagein. This first Chinese case of an empyema co-infected with S. cardiffensis and S. oralis highlights diagnostic challenges and provides crucial susceptibility guidance.
沙利亚菌感染并不常见，卡迪夫沙利亚菌感染极为罕见。一名66岁对青霉素过敏的女性出现发热、咳嗽和脓性痰。胸部计算机断层扫描显示双侧肺炎、右侧局限性脓胸和右下叶肺不张。初始引流培养仅鉴定出口腔链球菌，但随后的厌氧富集和16S rRNA基因测序证实为卡迪夫沙利亚菌，一种专性厌氧菌。由于缺乏药敏数据，我们建立了卡迪夫沙利亚菌的初始药敏谱。使用替代抗生素联合经皮引流成功实现了治疗。这例首例中国的同时感染卡迪夫沙利亚菌和口腔链球菌的脓胸病例突出了诊断挑战并提供了关键的药敏指导。
