脑结构-功能耦合破坏及其对脑小血管病负担与认知功能障碍之间关联的中介作用
Disrupted Brain Structure-Function Coupling and Its Mediating Effects on the Associations Between Cerebral Small Vessel Disease Burden and Cognitive Dysfunction.
作者信息
Wang Na, Guo Lingfei, Gao Yian, Sui Chaofan, Zhang Xinyue, Wang Yuanyuan, Fu Yajie, Zhang Nan, Che Yena, Wen Hongwei, Liang Changhu
机构信息
Key Laboratory of Endocrine Glucose and Lipids Metabolism and Brain Aging, Ministry of Education, Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Department of Radiology, China-Japan Friendship Hospital (Institute of Clinical Medical Sciences), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
出版信息
CNS Neurosci Ther. 2025 Sep;31(9):e70604. doi: 10.1111/cns.70604.
AIMS
We aimed to specify relationships among cerebral small vessel disease (CSVD) burden, cognitive dysfunction, and brain structure-function coupling changes.
METHODS
A total of 108 patients with mild CSVD burden (CSVD-m), 53 patients with severe CSVD burden (CSVD-s), and 76 healthy controls (HC) were included in this study. The ratio of regional homogeneity (ReHo) or amplitude of low-frequency fluctuation (ALFF) to gray matter volume (GMV) was calculated as an indicator of voxel-wise structure-function coupling.
RESULTS
Significantly decreased or increased ReHo-GMV and ALFF-GMV coupling values in patients with severe CSVD burden were primarily found in several brain regions, and the disrupted structure-function coupling in the right putamen mediated the relationship between CSVD burden and cognitive dysfunction.
CONCLUSIONS
Brain structure-function coupling characterized by ReHo-GMV and ALFF-GMV mediated the cognitive dysfunction caused by CSVD and was an innovative and effective brain imaging indicator for exploring the association between CSVD burden and cognitive dysfunction.
目的
我们旨在明确脑小血管病（CSVD）负担、认知功能障碍和脑结构 - 功能耦合变化之间的关系。
方法
本研究共纳入108例轻度CSVD负担患者（CSVD - m）、53例重度CSVD负担患者（CSVD - s）和76名健康对照者（HC）。计算局部一致性（ReHo）或低频振幅（ALFF）与灰质体积（GMV）的比值，作为体素水平结构 - 功能耦合的指标。
结果
重度CSVD负担患者中，ReHo - GMV和ALFF - GMV耦合值显著降低或升高，主要出现在几个脑区，右侧壳核中结构 - 功能耦合的破坏介导了CSVD负担与认知功能障碍之间的关系。
结论
以ReHo - GMV和ALFF - GMV为特征的脑结构 - 功能耦合介导了CSVD所致的认知功能障碍，是探索CSVD负担与认知功能障碍之间关联的一种创新且有效的脑成像指标。
Zotero 插件