Hopf G, Böcker R, Estler C J
Arch Int Pharmacodyn Ther. 1985 Nov;278(1):157-68.
The effects of tetracycline and doxycycline (25 and 100 micrograms/g i.v.) on serum GOT, GPT, urea, bilirubin, cholesterol and triglycerides and on the hepatic cholesterol and triglyceride levels have been investigated comparatively in female mice of two age groups: young adult and old. Both tetracyclines caused increases in the serum transaminases and bilirubin and in the triglyceride and cholesterol contents of the liver that were less pronounced in old than in young adult mice. The reason for the age difference may be that doxycycline and tetracycline accumulated to a greater extent in the livers of the younger age group. Only the rise of the serum urea levels after tetracycline and doxycycline was greater in old mice than in the young adults.
在两个年龄组的雌性小鼠（成年和老年）中，比较研究了四环素和强力霉素（静脉注射，剂量分别为25微克/克和100微克/克）对血清谷草转氨酶（GOT）、谷丙转氨酶（GPT）、尿素、胆红素、胆固醇和甘油三酯以及肝脏胆固醇和甘油三酯水平的影响。两种四环素均导致血清转氨酶、胆红素以及肝脏甘油三酯和胆固醇含量升高，老年小鼠的升高程度低于成年小鼠。年龄差异的原因可能是强力霉素和四环素在年轻年龄组小鼠肝脏中的蓄积程度更高。仅四环素和强力霉素给药后老年小鼠血清尿素水平的升高幅度大于成年小鼠。
