Böcker R, Estler C J, Müller S, Pfandzelter C, Spachmüller B
Arzneimittelforschung. 1982;32(3):237-41.
A comparative study was made on the effects of tetracycline (TC), rolitetracycline (RTC), and doxycycline (DC) at doses of 10-100 micrograms/g i.v. on serum GOT, GPT, bilirubin and urea levels of male and female mice. All tetracyclines at doses of 50-100 micrograms/g caused an increase of serum GOT and GPT activities in females after 2-8 h. This effect was less pronounced in males. The serum urea levels were markedly raised by TC and DC (50-100 micrograms/g) and RTC (10-100 micrograms/g). This effect was produced only in females. It was long-lasting (up to 8 h) after TC and RTC and more transient after DC. Likewise the tetracyclines affected the serum bilirubin only in females but not in males. All tetracyclines (25-100 micrograms/g) increased the amount of unconjugated and total bilirubin. This effect was most pronounced after TC, which also reduced the level of conjugated bilirubin.
对静脉注射剂量为10 - 100微克/克的四环素（TC）、罗利环素（RTC）和强力霉素（DC）对雄性和雌性小鼠血清谷草转氨酶（GOT）、谷丙转氨酶（GPT）、胆红素和尿素水平的影响进行了一项比较研究。剂量为50 - 100微克/克的所有四环素在2 - 8小时后会导致雌性小鼠血清GOT和GPT活性升高。这种作用在雄性小鼠中不太明显。TC和DC（50 - 100微克/克）以及RTC（10 - 100微克/克）会使血清尿素水平显著升高。这种作用仅在雌性小鼠中产生。TC和RTC作用后持续时间长（长达8小时），DC作用后持续时间较短。同样，四环素仅对雌性小鼠的血清胆红素产生影响，对雄性小鼠无影响。所有四环素（25 - 100微克/克）都会增加未结合胆红素和总胆红素的量。TC作用后这种影响最为明显，它还会降低结合胆红素水平。
