Böcker R, Warnke L, Estler C J
Arzneimittelforschung. 1984;34(4):446-8.
In mice treated with 50 micrograms/g i.v. tetracycline (TC) or doxycycline (DC), respectively, drug concentrations have been measured in serum, whole blood, liver, kidneys, lungs, heart, skeletal muscle and bones. TC reached especially high concentrations in liver, kidneys and bones. DC was initially trapped by lung tissue and accumulated in liver and kidneys. Liver concentrations were higher for TC, kidney concentrations were higher for DC. In some tissues, e.g. liver and kidneys, TC and DC reached higher concentrations in females than in males.
分别用50微克/克静脉注射四环素（TC）或强力霉素（DC）处理小鼠后，已测定血清、全血、肝脏、肾脏、肺、心脏、骨骼肌和骨骼中的药物浓度。TC在肝脏、肾脏和骨骼中达到特别高的浓度。DC最初被肺组织捕获，并在肝脏和肾脏中积累。TC的肝脏浓度较高，DC的肾脏浓度较高。在一些组织中，如肝脏和肾脏，TC和DC在雌性小鼠中的浓度高于雄性小鼠。
