从人肾皮质分离的刷状缘小泡对脯氨酸的摄取。

Uptake of proline by brushborder vesicles isolated from human kidney cortex.

作者信息

Foreman J W, McNamara P D, Pepe L M, Ginkinger K, Segal S

出版信息

Biochem Med. 1985 Dec;34(3):304-9. doi: 10.1016/0006-2944(85)90092-4.

Abstract

Proline transport into renal brushborder membrane vesicles isolated from human kidney is mediated by two uptake systems. The high-affinity system is stimulated by a Na gradient and appears to be shared with glycine while the low-affinity system is not. Uptake curves of low concentrations of proline exhibit a Na-gradient-dependent overshoot indicative of electrogenic transport. The proline transport systems observed in isolated human renal brushborder membrane vesicles appear to have characteristics similar to those in rat kidney membranes.

摘要

脯氨酸转运进入从人肾分离的肾刷状缘膜囊泡是由两种摄取系统介导的。高亲和力系统受钠梯度刺激，似乎与甘氨酸共用，而低亲和力系统则不然。低浓度脯氨酸的摄取曲线呈现出钠梯度依赖性过冲，表明是电生成转运。在分离的人肾刷状缘膜囊泡中观察到的脯氨酸转运系统似乎具有与大鼠肾膜中相似的特征。