新生大鼠肾刷状缘膜囊泡对L-脯氨酸的转运
L-proline transport by newborn rat kidney brush-border membrane vesicles.
作者信息
Goldmann D R, Roth K S, Langfitt T W, Segal S
出版信息
Biochem J. 1979 Jan 15;178(1):253-6. doi: 10.1042/bj1780253.
Abstract
The transport of L-proline was studied in brush-border membrane vesicles isolated from the kidneys of newborn rats. In contrast with the rapid initial uptake with an 'overshoot' observed in adult vesicles, uptake by the newborn vesicle was slow, showed no 'overshoot', and proline continued to accumulate at a time when the adult vesicle had already equilibrated. L-Proline transport in the newborn rat occurs by Na+-dependent and independent mechanisms. There appeared to be essentially no uptake by anti-luminal vesicles isolated from newborn rat kidney. These observations may help to explain the prolinuria that occurs in the newborn animal.
摘要
对从新生大鼠肾脏分离出的刷状缘膜囊泡中L-脯氨酸的转运进行了研究。与成年囊泡中观察到的具有“超射”现象的快速初始摄取相反，新生囊泡的摄取缓慢，没有“超射”现象，并且在成年囊泡已经达到平衡时，脯氨酸仍在继续积累。新生大鼠体内的L-脯氨酸转运通过钠依赖性和非依赖性机制进行。从新生大鼠肾脏分离出的抗腔面膜囊泡基本没有摄取现象。这些观察结果可能有助于解释新生动物中出现的脯氨酸尿症。
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