Stache U, Fritsch W, Rupp H, Hitzel V, Fehlhaber H W
Arzneimittelforschung. 1985;35(12):1753-7.
The synthesis of prednisolone-17-ethylcarbonate-21-propionate (5) (prednicarbate, Hoe 777) passing the intermediate products prednisolone-17,12-diethylorthocarbonate (2) and prednisolone-17-ethylcarbonate (3) as well as some physicochemical properties and spectroscopic data of (5), especially the 1H-NMR- and MS-spectrum, are reported. Prednicarbate has an optimal split of topical/systemic antiinflammatory activity.
报道了通过中间体泼尼松龙-17,12-二碳酸乙酯（2）和泼尼松龙-17-碳酸乙酯（3）合成泼尼松龙-17-碳酸乙酯-21-丙酸酯（5）（泼尼卡酯，Hoe 777），以及（5）的一些物理化学性质和光谱数据，特别是1H-NMR和质谱。泼尼卡酯具有局部/全身抗炎活性的最佳分布。
