有效抗高血压药物利奥地平的制备与性质
Preparation and properties of ryodipine, an effective antihypertensive agent.
作者信息
Kastron V V, Dubur G J, Shatz V D, Yagupolsky L M
出版信息
Arzneimittelforschung. 1985;35(4):668-72.
PMID:4015732
Abstract
A novel effective antihypertensive agent, 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(o-difluoromethoxyphenyl++ +)-1,4-dihydropyridine (ryodipine, PP-1466) has been obtained. A method for ryosidine synthesis has been developed, side products of PP-1466 synthesis have been isolated and identified. Special characteristics (IRS, UVS, NMR, MS) and chromatography data (TLC, HPLC) are cited.
摘要
已获得一种新型有效的抗高血压药物，即2,6 - 二甲基 - 3,5 - 二甲氧基羰基 - 4 - （邻 - 二氟甲氧基苯基）-1,4 - 二氢吡啶（利奥地平，PP - 1466）。已开发出一种利奥苷的合成方法，分离并鉴定了PP - 1466合成的副产物。引用了其特殊性质（红外光谱、紫外光谱、核磁共振、质谱）和色谱数据（薄层色谱、高效液相色谱）。
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