Di Stanislao F, Bordicchia F, Strusi P, Renga G
Boll Ist Sieroter Milan. 1985;64(6):447-54.
Tetanus antitoxin levels were measured in a non-random group of 281 subjects of pediatric age, using a passive haemagglutination technique. 94.7% of sera had protective antitoxin levels (titer greater than or equal to 1: 1024), while the other ones had levels usually considered as partly protective (titer of 1:256 or 1:512). Subjects who completed vaccination schedule had protective levels also 6 or more years after last dose. Subjects with partly protective antitoxin levels can be identified reviewing vaccination registers and recalling people who did not complete vaccination schedule. This procedure, if used as screening test, has sensitivity of 20%, specificity of 98% and a predictive value of positive tests of 37.5%. The quality of vaccination service of the study area, assessed using three indicators, resulted fairly good.
采用被动血凝技术,对281名儿童进行了破伤风抗毒素水平的测定,该组并非随机选取。94.7%的血清具有保护性抗毒素水平(效价大于或等于1:1024),而其他血清的水平通常被认为具有部分保护作用(效价为1:256或1:512)。完成疫苗接种程序的受试者在最后一剂疫苗接种6年或更长时间后仍具有保护性水平。通过查阅疫苗接种记录并召回未完成疫苗接种程序的人员,可以识别出抗毒素水平具有部分保护作用的受试者。如果将该程序用作筛查试验,其敏感性为20%,特异性为98%,阳性试验预测值为37.5%。使用三项指标评估的研究区域疫苗接种服务质量相当不错。