Andrade-Ortega Bernardo, Díaz Héctor, Bayones Lucas, Alvarez Manuel, Zainos Antonio, Rivera-Yoshida Natsuko, Franci Alessio, Romo Ranulfo, Rossi-Pool Román
Instituto de Fisiología Celular ─ Neurociencias, Universidad Nacional Autónoma de México, 04510 Mexico City, Mexico.
Montefiore Institute, University of Liège, Av de la Découverte 10, 4000 Liège, Belgique.
Sci Adv. 2025 Sep 19;11(38):eadw5500. doi: 10.1126/sciadv.adw5500.
How neurons in the ventral premotor cortex (VPC) integrate and process multimodal sensory information remains unclear. We recorded VPC neuronal activity in two monkeys performing a tactile or acoustic bimodal detection task (BDT). Single-cell analyses revealed purely tactile, purely acoustic, bimodal, and decision-mnemonic responses. Population analyses of the VPC network and a recurrent neural network trained on the BDT uncovered notably similar latent dynamics. In both networks, neural trajectories diverged sharply from rest along modality-specific directions during stimulus presentation, while remained at rest during stimulus-absent trials. Subsequently, trajectories rotated toward a mnemonic subspace, where perceptual decisions (acoustic, tactile, and absent) were maintained in three distinctly different stable attractors. Using low-dimensional modeling, we propose a universal mechanism for the transition from sensory processing to memory retention explaining both biological and artificial latent neural dynamics in a simple dynamical motif. These results show that VPC neurons encode bimodal information, can integrate competing sensory inputs, and maintain multimodal perceptual decisions.
腹侧运动前皮层（VPC）中的神经元如何整合和处理多模态感觉信息仍不清楚。我们记录了两只执行触觉或听觉双模态检测任务（BDT）的猴子的VPC神经元活动。单细胞分析揭示了纯触觉、纯听觉、双模态和决策记忆反应。对VPC网络和在BDT上训练的循环神经网络进行的群体分析发现了明显相似的潜在动力学。在两个网络中，在刺激呈现期间，神经轨迹沿着特定模态方向从静止状态急剧发散，而在无刺激试验期间保持静止。随后，轨迹向记忆子空间旋转，在那里，感知决策（听觉、触觉和无刺激）在三个明显不同的稳定吸引子中得以维持。通过低维建模，我们提出了一种从感觉处理到记忆保留转变的通用机制，用一个简单的动力学基序解释了生物和人工潜在神经动力学。这些结果表明，VPC神经元编码双模态信息，能够整合相互竞争的感觉输入，并维持多模态感知决策。
