Kenrick K G, Walker-Smith J A
Gut. 1970 Aug;11(8):635-40. doi: 10.1136/gut.11.8.635.
Twenty-four children with coeliac disease were compared with a control group, comprising 17 children with a variety of gastroenterological disorders, with respect to serum immunoglobulins and dietary protein antibodies. Elevated levels of IgA and abnormally low levels of IgM were demonstrated in one third of the coeliac patients. Antibodies to at least one of eight dietary proteins were found in 50% of coeliac children. Three children with raised levels of serum IgA and two with deficient IgM were re-examined after varying periods on a gluten-free diet. Antibodies to dietary proteins had waned and immunoglobulin levels returned to normal in all cases. The raised IgA was considered to have resulted from an extensive immunological response to antigens of dietary origin which had entered through the abnormal gut mucosa. It is suggested that IgM deficiency was due to specific inhibition of IgM synthesis by dietary components which had also entered through the mucosa.
将24名患有乳糜泻的儿童与一个对照组进行了比较，该对照组由17名患有各种胃肠疾病的儿童组成，比较内容为血清免疫球蛋白和膳食蛋白抗体。三分之一的乳糜泻患者显示IgA水平升高和IgM水平异常降低。50%的乳糜泻儿童体内发现了针对八种膳食蛋白中至少一种的抗体。三名血清IgA水平升高的儿童和两名IgM缺乏的儿童在食用无麸质饮食不同时间段后接受了复查。所有病例中，膳食蛋白抗体均已减弱，免疫球蛋白水平恢复正常。升高的IgA被认为是由于对通过异常肠黏膜进入的膳食来源抗原产生了广泛的免疫反应所致。有人提出，IgM缺乏是由于同样通过黏膜进入的膳食成分对IgM合成的特异性抑制。
