Thakur M L, Segal A W, Louis L, Welch M J, Hopkins J, Peters T J
J Nucl Med. 1977 Oct;18(10):1022-6.
Human neutrophils were labeled with In-111 oxine by incubation at room temperature, and the fate of the oxine and the intracellular location of the In-111 were determined. Neutral (1:3) In-111 oxine complex diffuses rapidly across the cell membrane and then dissociates. Some of the oxine leaves the cell and the In-111 binds intracellularly. After short periods of incubation the label is distributed mostly to four soluble components, a small proportion of which had a distribution similar to that of specific and azurophil granules. After longer incubation periods there was relatively less radioactivity with the soluble components and probably more attached to the particulate material. A small peak of radioactivity also appeared in the region of DNA distribution, but no confirmation could be obtained for the association of the In-111 radioactivity with DNA.
将人类中性粒细胞在室温下与铟 - 111 奥克辛孵育进行标记，然后确定奥克辛的去向以及铟 - 111 在细胞内的定位。中性（1:3）铟 - 111 奥克辛复合物迅速扩散穿过细胞膜，然后解离。部分奥克辛离开细胞，铟 - 111 在细胞内结合。孵育短时间后，标记物主要分布于四种可溶性成分，其中一小部分的分布类似于特异性颗粒和嗜天青颗粒。孵育较长时间后，可溶性成分中的放射性相对较少，可能更多地附着于颗粒物质。在 DNA 分布区域也出现了一个小的放射性峰值，但无法证实铟 - 111 放射性与 DNA 的关联。
