Taylor G, Odili J L
Br J Cancer. 1970 Sep;24(3):447-53. doi: 10.1038/bjc.1970.53.
An autoantibody response against a breast carcinoma tumour specific neoantigen is described. The antigen, which was present in 6 of 11 breast carcinomata examined, was shown to have similarities to the T antigen of DNA virus induced animal tumours. In addition a different antigen (or antigenic determinant) was shown to be present in one breast carcinoma. This was not strictly tumour specific, being present in lower concentration in normal breast from the same individual.
本文描述了针对一种乳腺癌肿瘤特异性新抗原的自身抗体反应。在检测的11例乳腺癌中,有6例存在该抗原,它与DNA病毒诱导的动物肿瘤的T抗原有相似性。此外,在一例乳腺癌中还发现了一种不同的抗原(或抗原决定簇)。该抗原并非严格的肿瘤特异性抗原,在同一个体的正常乳腺组织中也有较低浓度的存在。