Sandeno Elsa, Karachenets Sergey, Zehlke Kourtney, Khan Raza, Kalinoski Michael, Meshram Pravin, Harmon James V
University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Department of Medicine, M Health Fairview Ridges Hospital, Burnsville, MN 55337, USA.
Toxicol Rep. 2025 Aug 16;15:102114. doi: 10.1016/j.toxrep.2025.102114. eCollection 2025 Dec.
A 40-year-old man presented to the emergency department within 6 h of a massive overdose of 500 units of long-acting feline glargine insulin intravenously and an estimated 50 mg of clozapine. Upon initial assessment, his Glasgow Coma Scale (GCS) was 15 and his blood sugar level was 45 mg/dL. The patient was successfully managed with dextrose infusions and close monitoring of blood sugar and electrolytes. To date, no cases have been documented in the literature describing an overdose of insulin formulation intended for veterinary use. Cases of overdose with animal-prescribed human insulin analogs can be managed similarly to previously reported cases of human insulin overdose.
一名40岁男性在静脉注射500单位长效猫用甘精胰岛素及约50毫克氯氮平大量过量摄入后6小时内被送往急诊科。初步评估时,他的格拉斯哥昏迷量表(GCS)评分为15分,血糖水平为45毫克/分升。患者通过葡萄糖输注以及对血糖和电解质的密切监测得到了成功救治。迄今为止,文献中尚无描述兽用胰岛素制剂过量的病例记录。动物专用人胰岛素类似物过量的病例可参照先前报道的人胰岛素过量病例进行处理。