儿童和青少年的P300反应：年龄和刺激效应。
P300 response among children and adolescents: Age and stimulus effects.
作者信息
Gupta Sangeeta, Prasad Arun, Gupta Gaurav
机构信息
Department of Physiology, All India Institute of Medical Sciences (AIIMS) Gorakhpur, Uttar Pradesh, India.
Department of Paediatrics, All India Institute of Medical Sciences (AIIMS) Patna, Bihar, India.
出版信息
Bioinformation. 2025 Jun 30;21(6):1332-1339. doi: 10.6026/973206300211332. eCollection 2025.
The association between age and P300 components and also the influence of stimulus-related variations, particularly intensity and probability in children and adolescents is of interest. P300 amplitude and latency and the effects of stimulus variation on P300 components were measured in 60 subjects in the age-group of 5-18 years and analysed with one-way ANOVA. P < 0.05 was considered as statistically significant. Mean P300 latency decreased and mean N2-P3 amplitudes increased with statistical significance (p<0.001) (one-way ANOVA) with substantially greater changes till 8-11 years of age. P300 latency varied inversely with stimulus intensity and probability while N2-P3 amplitude varied positively with stimulus intensity and adversely with change in the probability in all the age-groups (p<0.001) (one-way ANOVA). Age affects both P300 latency and amplitude in the children and adolescents in a characteristic pattern and stimulus variations affect the P300 responses relatively uniformly in different younger age-groups.
年龄与P300成分之间的关联，以及刺激相关变量，特别是强度和概率对儿童及青少年的影响备受关注。对60名5至18岁年龄组的受试者测量了P300波幅和潜伏期以及刺激变量对P300成分的影响，并采用单因素方差分析进行分析。P < 0.05被认为具有统计学意义。平均P300潜伏期缩短，平均N2 - P3波幅增加，具有统计学意义（p<0.001）（单因素方差分析），直至8至11岁时变化更为显著。在所有年龄组中，P300潜伏期与刺激强度和概率呈反比，而N2 - P3波幅与刺激强度呈正比，与概率变化呈反比（p<0.001）（单因素方差分析）。年龄以一种特征性模式影响儿童及青少年的P300潜伏期和波幅，刺激变量在不同的低龄组中对P300反应的影响相对一致。
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