Kuba Miroslav, Kremláček Jan, Langrová Jana, Kubová Zuzana, Szanyi Jana, Vít František
Faculty of Medicine in Hradec Králové, Dept. of Pathophysiology, Electrophysiological Laboratory, Charles University in Prague, Hradec Králové, Czech Republic.
Vision Res. 2012 Jun 1;62:9-16. doi: 10.1016/j.visres.2012.03.014. Epub 2012 Apr 4.
An electrophysiological study on the effect of aging on the visual pathway and various levels of visual information processing (primary cortex, associate visual motion processing cortex and cognitive cortical areas) was performed. We examined visual evoked potentials (VEPs) to pattern-reversal, motion-onset (translation and radial motion) and visual stimuli with a cognitive task (cognitive VEPs - P300 wave) at luminance of 17 cd/m(2). The most significant age-related change in a group of 150 healthy volunteers (15-85 years of age) was the increase in the P300 wave latency (2 ms per 1 year of age). Delays of the motion-onset VEPs (0.47 ms/year in translation and 0.46 ms/year in radial motion) and the pattern-reversal VEPs (0.26 ms/year) and the reductions of their amplitudes with increasing subject age (primarily in P300) were also found to be significant. The amplitude of the motion-onset VEPs to radial motion remained the most constant parameter with increasing age. Age-related changes were stronger in males. Our results indicate that cognitive VEPs, despite larger variability of their parameters, could be a useful criterion for an objective evaluation of the aging processes within the CNS. Possible differences in aging between the motion-processing system and the form-processing system within the visual pathway might be indicated by the more pronounced delay in the motion-onset VEPs and by their preserved size for radial motion (a biologically significant variant of motion) compared to the changes in pattern-reversal VEPs.
我们进行了一项关于衰老对视神经通路及不同水平视觉信息处理（初级皮层、视觉运动关联处理皮层和认知皮层区域）影响的电生理研究。我们在17 cd/m²的亮度下，检测了对模式翻转、运动起始（平移和径向运动）以及带有认知任务（认知视觉诱发电位 - P300波）的视觉刺激的视觉诱发电位（VEP）。在150名健康志愿者（年龄在15 - 85岁之间）中，与年龄最显著相关的变化是P300波潜伏期增加（每年增加2毫秒）。还发现运动起始VEP（平移时每年延迟0.47毫秒，径向运动时每年延迟0.46毫秒）和模式翻转VEP（每年延迟0.26毫秒）随着受试者年龄增加而延迟，并且其波幅降低（主要是P300）也很显著。随着年龄增加，径向运动的运动起始VEP波幅是最稳定的参数。年龄相关变化在男性中更明显。我们的结果表明，认知VEP尽管其参数变异性较大，但可能是客观评估中枢神经系统内衰老过程的有用标准。与模式翻转VEP的变化相比，运动起始VEP更明显的延迟以及其对径向运动（一种生物学上重要的运动变体）的波幅保持情况，可能表明视觉通路内运动处理系统和形式处理系统在衰老方面存在潜在差异。
