An Ran, Wang Xiaolei, Xiong Ligui, Yang Yanqi, Li Peiling
Department of Obstetrics and Gynecology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, P.R. China.
Department of Immunology and Rheumatology, Cangzhou Hospital of Integrated TCM-WM Hebei, Cangzhou, Hebei, P.R. China.
J Clin Transl Sci. 2025 Aug 29;9(1):e186. doi: 10.1017/cts.2025.10097. eCollection 2025.
We deliberated a case report of seven cases to investigate whether inhibitors of tumor necrosis factor-α (TNF-) could reduce pregnancy dangers caused by antiphospholipid syndrome (APS). Patient 1 was diagnosed with NC-OAPS and Hashimoto, Patient 3 was with SN-APS and Hashimoto, Patient 2, 3, 4 were with SN-APS, Patient 5 and 6 were with OAPS, and Patient 7 was with OAPS and PCOS. Patient 4 took the longest period to report the disappearance of symptoms (7 days), followed by patients 1 and 5, and lastly, 2, 3, 6 and 7; after treatment, TNF-α decreased to varying degrees in 7 patients, among which Patient 1, 3, 6, 7 reached the ideal level (< 8.1) and Patient 5 reached the highest level (123.04); Patient 6 and 7 were ongoing pregnancies. The fetuses were born to the desired gestational age except the fetus from Patient 1. A total of 5 patients underwent cesarean delivery. The average height of the newborns was 48.20 cm and the average weight was 2.50 kg. The Apgar scores ranged between 8 and 10. The ongoing pregnancies as a limitation of the dataset. Collectively, we found that TNF-α Inhibitors could prolong gestational period.
我们仔细研究了一份包含七例病例的报告，以调查肿瘤坏死因子-α（TNF-α）抑制剂是否能降低抗磷脂综合征（APS）所致的妊娠风险。患者1被诊断为非典型APS（NC-OAPS）合并桥本氏病，患者3为继发性APS（SN-APS）合并桥本氏病，患者2、3、4患有SN-APS，患者5和6患有原发性APS（OAPS），患者7患有OAPS和多囊卵巢综合征（PCOS）。患者4报告症状消失所需时间最长（7天），其次是患者1和5，最后是患者2、3、6和7；治疗后，7例患者的TNF-α均有不同程度下降，其中患者1、3、6、7降至理想水平（<8.1），患者5降至最高水平（123.04）；患者6和7持续妊娠。除患者1的胎儿外，其余胎儿均在预期孕周出生。共有5例患者接受剖宫产。新生儿平均身高48.20厘米，平均体重2.50千克。阿氏评分在8至10分之间。本数据集存在持续妊娠这一局限性。总体而言，我们发现TNF-α抑制剂可延长妊娠期。
