Ershova E S, Umriukhin P E, Zinchenko R A, Vasilieva T P, Kostyuk S E, Shabalin N Yu, Salimova T A, Malinovskaya E M, Veiko N N, Kostyuk S V
Laboratory of Molecular Biology, Research Centre for Medical Genetics, Moscow, Russia.
Institute of Longevity with a Clinic of Rehabilitation and Preventive Medicine, State Scientific Center of the Russian Federation, Russian Scientific Center of Surgery Named After Academician B. V. Petrovsky, Moscow, Russia.
J Aging Res. 2025 Sep 11;2025:8847073. doi: 10.1155/jare/8847073. eCollection 2025.
The variation of ribosomal (parameter ), satellite III (1q12) (parameter ), and telomere (parameter ) tandem repeats content of the human genome was studied in DNA samples isolated from blood leukocytes of 535 people whose age varied from 5 to 101 years. For analysis we used the method of nonradioactive quantitative hybridization. The group of centenarians (90-101 years old, = 106) differs from other age groups by a significantly narrower distribution of the ribosomal repeat content in DNA, a much higher content of satellite III, and a lower content of telomere repeat. A negative correlation was found between the and parameters ( < 10). The findings of this study suggest that the calculated parameters and exhibit a marked increase with age, culminating in maximal values within the cohort of centenarians. These results imply that the parameters , , and may hold the potential to serve as reliable predictors of life expectancy for individuals in advanced age.
在从535名年龄在5岁至101岁之间的人的血液白细胞中分离出的DNA样本中，研究了人类基因组中核糖体（参数）、卫星III（1q12）（参数）和端粒（参数）串联重复序列含量的变化。为了进行分析，我们使用了非放射性定量杂交方法。百岁老人组（90 - 101岁，n = 106）与其他年龄组的不同之处在于，DNA中核糖体重复序列含量的分布明显更窄，卫星III的含量高得多，端粒重复序列的含量更低。在参数α和β之间发现了负相关（p < 0.01）。本研究结果表明，计算出的参数α和β随年龄显著增加，在百岁老人队列中达到最大值。这些结果意味着参数α、β和γ可能有潜力作为高龄个体预期寿命的可靠预测指标。
