McGonagle Kathryn E, Lyall Vikram S, Taylor Cristina E, Rezaee Michael E
Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA.
Section of Urology, Department of Surgery, Dartmouth Hitchcock Medical Center, NH, 03766, USA.
Urol Case Rep. 2025 Aug 31;63:103194. doi: 10.1016/j.eucr.2025.103194. eCollection 2025 Nov.
Tamm-Horsfall protein (THP) is the most abundant protein in urine, yet its function remains incompletely understood. It has been hypothesized that THP contributes to the maintenance of urinary homeostasis. We report a case of a 71-year-old male with a history of renal cell carcinoma treated with partial nephrectomy in 2017. He represented 8 years later with an enlarging, enhancing renal mass concerning for recurrence. A radical nephrectomy was performed and revealed a benign specimen with a positive PAS stain, consistent with THP. To our knowledge this is the first report of THP deposition in the renal parenchyma after partial nephrectomy.
Tamm-Horsfall蛋白（THP）是尿液中含量最丰富的蛋白质，但其功能仍未完全明确。据推测，THP有助于维持尿液内环境稳定。我们报告一例71岁男性患者，其有肾细胞癌病史，于2017年接受了部分肾切除术。8年后，他因肾脏肿物增大且强化，怀疑复发前来就诊。遂行根治性肾切除术，术后病理显示标本为良性，PAS染色阳性，符合THP表现。据我们所知，这是首例关于部分肾切除术后THP在肾实质沉积的报道。
