Drane Quentin H, Ziegler Andrea, Thorpe Eric J
Creighton University School of Medicine, Omaha, Nebraska.
Department of Otolaryngology - Head and Neck Surgery, Loyola University Medical Center, Maywood, Illinois.
Adv Radiat Oncol. 2025 Jul 24;10(10):101873. doi: 10.1016/j.adro.2025.101873. eCollection 2025 Oct.
Osteoradionecrosis (ORN) is a serious complication following radiation therapy (RT) for head and neck cancers, commonly affecting the mandible, but is less understood when involving the hyoid bone.
A literature review through PubMed and Scopus identified 16 relevant articles. Patient characteristics, presentation, imaging findings, management, and outcomes are highlighted.
The review found 40 cases of hyoid bone ORN, with an average patient age of 60.0 years. Most patients were male (87.5%) and had oropharyngeal tumors (77.5%). The average RT dose was 66.2 Gy, and ORN typically developed 27.6 months after RT. Patients receiving concurrent radiation and chemotherapy were more likely to need surgery compared with those treated with RT alone (80% vs 30%, = .0042).
While rare, hyoid bone ORN may become more common with increasing rates of oropharyngeal cancers. Clinicians should be aware of presenting symptoms and possible complications and be familiar with a thorough work-up and treatment.
放射性骨坏死（ORN）是头颈部癌症放射治疗（RT）后的一种严重并发症，通常影响下颌骨，但舌骨受累时了解较少。
通过PubMed和Scopus进行文献综述，确定了16篇相关文章。重点介绍了患者特征、表现、影像学检查结果、治疗方法和结果。
该综述发现40例舌骨ORN病例，患者平均年龄为60.0岁。大多数患者为男性（87.5%），患有口咽肿瘤（77.5%）。平均放疗剂量为66.2 Gy，ORN通常在放疗后27.6个月出现。与单纯接受放疗的患者相比，同时接受放疗和化疗的患者更有可能需要手术（80%对30%，P = 0.0042）。
虽然罕见，但随着口咽癌发病率的增加，舌骨ORN可能会变得更加常见。临床医生应了解其出现的症状和可能的并发症，并熟悉全面的检查和治疗方法。
