Cassidy Caitlin A, Edwards Jessie K, Gunderson Annika K, Abernathy Haley, Garrett Haley E, King Elise, Parker Cherese N Beatty, Starling Anne P, Ciccone Emily J, Boyce Ross M, Shook-Sa Bonnie E, Aiello Allison E
Department of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, NC.
Carolina Population Center, The University of North Carolina at Chapel Hill, NC.
PLOS Ment Health. 2025 Sep;2(9). doi: 10.1371/journal.pmen.0000410. Epub 2025 Sep 17.
A large body of research suggests that stress can affect how the immune system responds to vaccines. The impact of mental health disorders on humoral antibody response following immunization is not well understood, particularly for the COVID-19 vaccines. Leveraging a population-based longitudinal cohort assessing SARS-CoV-2 incidence in central North Carolina, we sought to investigate the relationship between mental health and immune response to vaccination. The 106 participants responded to biweekly surveys and contributed monthly serum samples that underwent SARS-CoV-2 spike antibody testing via enzyme-linked immunosorbent assay (ELISA). Utilizing weighted generalized linear models, we measured the association between depressive symptoms as recorded on the CESD-20 and quantitative antibody levels after COVID-19. Overall, we found modest differences in post-vaccination IgG between participants with depression and those without. Individuals with depressive symptoms had smaller initial antibody responses after vaccination (mean difference = -3.55, 95% CI = (-12.01, 4.90)). These results suggest that mental health disorders may affect immune response to vaccination.
大量研究表明，压力会影响免疫系统对疫苗的反应。心理健康障碍对免疫接种后体液抗体反应的影响尚未得到充分了解，尤其是对于新冠疫苗而言。利用一项基于人群的纵向队列研究来评估北卡罗来纳州中部的新冠病毒发病率，我们试图研究心理健康与疫苗免疫反应之间的关系。106名参与者每两周接受一次调查，并每月提供血清样本，通过酶联免疫吸附测定（ELISA）对其进行新冠病毒刺突抗体检测。利用加权广义线性模型，我们测量了CESD-20记录的抑郁症状与新冠疫苗接种后定量抗体水平之间的关联。总体而言，我们发现抑郁症患者和非抑郁症患者接种疫苗后的IgG存在适度差异。有抑郁症状的个体在接种疫苗后的初始抗体反应较小（平均差异=-3.55，95%置信区间=（-12.01，4.90））。这些结果表明，心理健康障碍可能会影响疫苗免疫反应。
