氯硝西泮治疗癫痫及其对其他抗惊厥药的影响。
Treatment of epilepsy with clonazepam and its effect on other anticonvulsants.
作者信息
Nanda R N, Johnson R H, Keogh H J, Lambie D G, Melville I D
出版信息
J Neurol Neurosurg Psychiatry. 1977 Jun;40(6):538-43. doi: 10.1136/jnnp.40.6.538.
Abstract
Clonazepam was added to the treatment of patients with poorly controlled epilepsy in a double-blind trial and an open trial. Considerable improvement occurred with patients with myoclonic jerks and tonic-clonic convulsions, and with photosensitive epilepsy. Patients with atypical petit mal and focal epilepsies also improved. Drowsiness was initially common but lasted only a short time. No evidence was found for an action of clonazepam on the metabolism of other drugs, but treatment with phenobarbitone lowered serum concentrations of clonazepam. We conclude that clonazepam is particularly valuable in epilepsy with associated myoclonsu and in photosensitive epilepsy.
摘要
在一项双盲试验和一项开放试验中，添加氯硝西泮用于治疗癫痫控制不佳的患者。肌阵挛性抽搐、强直阵挛性惊厥患者以及光敏性癫痫患者有显著改善。不典型失神发作和局灶性癫痫患者也有改善。嗜睡起初很常见，但仅持续很短时间。未发现氯硝西泮对其他药物代谢有作用的证据，但苯巴比妥治疗会降低氯硝西泮的血清浓度。我们得出结论，氯硝西泮在伴有肌阵挛的癫痫和光敏性癫痫中特别有价值。
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