Jian Enlin, Wang Mengping, Zhang Zhen, Heng Yiwei, Zhang Chengwei, Chen Qing, Yu Xiaoping, Zhu Yanfeng, Cai Peiling
School of Preclinical Medicine, Chengdu University, Chengdu, Sichuan, China.
Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Front Microbiol. 2025 Sep 5;16:1634803. doi: 10.3389/fmicb.2025.1634803. eCollection 2025.
Metabolic endotoxemia, characterized by chronic low-grade elevation of circulating bacterial endotoxins such as lipopolysaccharides derived from Gram-negative bacteria, has emerged as a central focus in metabolic disease research. Notably, emerging evidence highlights the pivotal role of gut microbiota in driving this condition, though critical knowledge gaps persist regarding the precise mechanisms mediated by gut microbiota-derived metabolites and their specific signaling pathways, as well as the development of individualized intervention strategies. To systematically map the evolving research landscape, this review employs bibliometric analysis to identify emerging trends and patterns in understanding the interplay between metabolic endotoxemia and gut microbial communities.
This study employed a comprehensive bibliometric analysis of scholarly literature indexed in the Web of Science Core Collection (1900-2024) to investigate research patterns in metabolic endotoxemia and gut microbiota. Through multidimensional examination using VOSviewer, CiteSpace, the bibliometrix R package, and the online bibliometric analysis platform (https://bibliometric.com/), we systematically mapped research priorities, collaborative networks, and evolving frontiers in this interdisciplinary field. The methodology incorporated advanced visualization techniques and quantitative assessments to identify thematic clusters, institutional contributions, and knowledge diffusion pathways within the extant literature corpus.
This comprehensive global analysis, encompassing 1,585 relevant studies, demonstrates compelling evidence that China and USA collectively contribute over 50% of scientific output in this specialized research domain. Notably, academic investigations into metabolic endotoxemia and gut microbiota continue to maintain substantial research momentum. Current scholarly discourse prominently features five key thematic clusters: gut dysbiosis, intestinal barrier, risk, gut-liver axis, and short-chain fatty acids.
This in-depth review systematically examines the evolving research landscape and emerging investigative priorities in metabolic endotoxemia and gut microbiota. It equips researchers with a comprehensive overview of key contributors in these specialized fields, including leading nations, institutions, academic journals, and potential collaborative networks. The analysis further delineates cutting-edge research frontiers and proposes strategic directions for future investigation, thereby serving as an invaluable resource for scholars navigating the complex interplay between metabolic endotoxemia and gut microbiota in the intestinal ecosystem.
代谢性内毒素血症的特征是循环中的细菌内毒素（如革兰氏阴性菌衍生的脂多糖）出现慢性低度升高，已成为代谢疾病研究的核心焦点。值得注意的是，新出现的证据凸显了肠道微生物群在引发这种状况中的关键作用，不过在由肠道微生物群衍生的代谢产物介导的精确机制及其特定信号通路，以及个性化干预策略的开发方面，仍存在重大知识空白。为了系统地描绘不断演变的研究格局，本综述采用文献计量分析来识别在理解代谢性内毒素血症与肠道微生物群落之间相互作用方面的新趋势和模式。
本研究对科学网核心合集（1900 - 2024年）中索引的学术文献进行了全面的文献计量分析，以调查代谢性内毒素血症和肠道微生物群的研究模式。通过使用VOSviewer、CiteSpace、文献计量学R包以及在线文献计量分析平台（https://bibliometric.com/）进行多维审视，我们系统地绘制了这个跨学科领域的研究重点、合作网络和不断演变的前沿领域。该方法纳入了先进的可视化技术和定量评估，以识别现有文献库中的主题集群、机构贡献和知识传播途径。
这项涵盖1585项相关研究的全面全球分析表明，中国和美国在这个专业研究领域的科学产出合计超过50%。值得注意的是，对代谢性内毒素血症和肠道微生物群的学术研究继续保持着强劲的研究势头。当前的学术讨论主要围绕五个关键主题集群展开：肠道菌群失调、肠道屏障、风险、肠 - 肝轴和短链脂肪酸。
本深度综述系统地审视了代谢性内毒素血症和肠道微生物群不断演变的研究格局及新出现的研究重点。它为研究人员提供了这些专业领域关键贡献者的全面概述，包括主要国家、机构、学术期刊和潜在的合作网络。该分析进一步描绘了前沿研究领域，并为未来研究提出了战略方向，从而成为学者们在肠道生态系统中探索代谢性内毒素血症与肠道微生物群之间复杂相互作用的宝贵资源。
