Williams Sha Neisha, Ding Wen-Xing
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA.
Department of Internal Medicine, Division of Gastroenterology, Hepatology & Motility, University of Kansas Medical Center, Kansas City, Kansas, USA.
Hepatol Commun. 2025 Sep 22;9(10). doi: 10.1097/HC9.0000000000000808. eCollection 2025 Oct 1.
The number of individuals aged 65 years and older is expected to grow significantly in the coming decades. As life expectancy improves, the likelihood of developing chronic diseases, such as liver diseases, rises sharply with age. Aging is characterized by 3 main categories of hallmarks: primary, antagonistic, and integrative hallmarks. These categories are also observed in the liver, which ages more slowly than other organs. In this review, we summarize the current understanding of the mechanisms of aging as they pertain to the liver. This includes aging-related structural and functional changes in the liver, the roles of liver parenchymal and nonparenchymal cells, oxidative stress, and the sirtuin 1 protein. We also discuss how aging may influence the development and therapeutic management of various common liver diseases, including ischemia-reperfusion injury, DILI, alcohol-associated liver disease, and metabolic dysfunction-associated liver diseases.
预计在未来几十年里，65岁及以上的老年人数量将显著增长。随着预期寿命的提高，患慢性疾病（如肝脏疾病）的可能性会随着年龄的增长而急剧上升。衰老的特征主要有三大类标志：原发性、拮抗性和综合性标志。在肝脏中也观察到了这些类别，肝脏的衰老速度比其他器官要慢。在本综述中，我们总结了目前对与肝脏相关的衰老机制的理解。这包括肝脏中与衰老相关的结构和功能变化、肝实质细胞和非实质细胞的作用、氧化应激以及沉默调节蛋白1。我们还讨论了衰老如何影响各种常见肝脏疾病的发生发展及治疗管理，包括缺血再灌注损伤、药物性肝损伤、酒精性肝病以及代谢功能障碍相关肝病。
