Mao Xinning, Lv Ke, Qi Weihui, Cheng Wenqiang, Li Tenghui, Sun Yueli, Jin Hongting, Pan Hao, Wang Dong
Department of Orthopaedics, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University (Hangzhou Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, PR China.
Department of Orthopaedics, Hangzhou Dingqiao Hospital, Hangzhou, Zhejiang, PR China.
Bone Res. 2025 Sep 23;13(1):78. doi: 10.1038/s41413-025-00455-8.
Sarcopenia, a progressive and systemic skeletal muscle disorder marked by the accelerated deterioration of both muscle function and mass, is highly prevalent among the elderly population, significantly contributing to an elevated risk of adverse outcomes, including falls, fractures, and muscle weakness. Clinical investigations have identified a strong correlation between sarcopenia and several prevalent degenerative skeletal muscle disorders. This correlation is attributed to imbalances in joint mechanics resulting from localized muscle atrophy and the influence of musculoskeletal secretory factors. In this review, we discuss the broader implications of sarcopenia and critically evaluate the currently established assessment methods. Furthermore, the clinical significance of prevalent musculoskeletal disorders (including osteoporosis, osteoarthritis, and spinal pathologies) in relation to sarcopenia, alongside the underlying mechanisms influencing this relationship, is summarized. Additionally, the effects of sarcopenia on the therapeutic efficacy of medications and surgical interventions for musculoskeletal conditions are reviewed. Sarcopenia is intricately linked to the onset, progression, and prognosis of musculoskeletal disorders. Future research should prioritize elucidating the potential mechanisms that connect muscle loss with skeletal muscle diseases, and investigating whether mitigating sarcopenia symptoms could decelerate the progression of these disorders, thereby paving new pathways for therapeutic interventions.
肌肉减少症是一种进行性全身性骨骼肌疾病，其特征是肌肉功能和质量加速衰退，在老年人群中高度普遍，显著增加了不良后果的风险，包括跌倒、骨折和肌肉无力。临床研究已经确定肌肉减少症与几种常见的退行性骨骼肌疾病之间存在密切关联。这种关联归因于局部肌肉萎缩导致的关节力学失衡以及肌肉骨骼分泌因子的影响。在这篇综述中，我们讨论了肌肉减少症的更广泛影响，并批判性地评估了目前已确立的评估方法。此外，总结了常见肌肉骨骼疾病（包括骨质疏松症、骨关节炎和脊柱疾病）与肌肉减少症相关的临床意义以及影响这种关系的潜在机制。此外，还综述了肌肉减少症对肌肉骨骼疾病药物治疗和手术干预疗效的影响。肌肉减少症与肌肉骨骼疾病的发生、发展和预后密切相关。未来的研究应优先阐明将肌肉流失与骨骼肌疾病联系起来的潜在机制，并研究减轻肌肉减少症症状是否可以减缓这些疾病的进展，从而为治疗干预开辟新途径。
