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黑腿病:一种病因不明的致命疾病。

Blackleg: A deadly disease with a hidden cause.

作者信息

Tyasningsih Wiwiek, Khairullah Aswin Rafif, Tang John Yew Huat, Effendi Mustofa Helmi, Rehman Saifur, Ma'ruf Ilma Fauziah, Wardhani Bantari Wisynu Kusuma, Moses Ikechukwu Benjamin, Budiastuti Budiastuti, Fauzia Kartika Afrida, Ahmad Riza Zainuddin, Fauziah Ima, Kusala Muhammad Khaliim Jati, Pratama Bima Putra, Kurniasih Dea Anita Ariani, Wibowo Syahputra

机构信息

Division of Veterinary Microbiology, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia.

Research Center for Veterinary Science, National Research and Innovation Agency (BRIN), Bogor, Indonesia.

出版信息

Open Vet J. 2025 Jun;15(6):2343-2354. doi: 10.5455/OVJ.2025.v15.i6.7. Epub 2025 Jun 30.

DOI:10.5455/OVJ.2025.v15.i6.7
PMID:40989646
原文链接:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12451119/
Abstract

Blackleg is an infectious disease that mainly affects cattle and rarely affects other ruminants. It is characterized by hemorrhagic blackleg myositis. is a highly pathogenic anaerobic, endospore-forming Gram- positive bacteria that causes blackleg disease. Blackleg disease was first reported in 1870, but the causative bacterium was not described until 1887. Clostridium chauvoei is found in grassland, fresh water, silage, soil, and the excrement of healthy animals. Cattle intestines and pasture soil have both been found to contain spores, suggesting that the infection is contracted by ingesting the spores. Significant lesions are less common in the heart and more common in the skeletal muscle. Anaerobic culture, polymerase chain reaction, immunodetection using fluorescent antibody tests, and immunohistochemistry are methods for identifying bacteria. The production of gas in animal tissues, known as emphysematous swelling, is a hallmark of blackleg illness. Swelling usually affects big muscles including the neck, shoulders, thighs, and hips. Most incidences of blackleg illness in cattle occur during the warmer months of the year, and the disease typically manifests seasonally. Penicillin treatment and surgical removal of the lesions, including fasciotomy, are recommended for infected animals that are not in danger of death. Vaccination is a crucial part of the health management of many livestock production enterprises and can prevent blackleg illness. Blackleg disease can be controlled by destroying the carcass and burning the top layer of soil to eradicate any remaining spores.

摘要

黑腿病是一种主要影响牛、很少影响其他反刍动物的传染病。其特征为出血性黑腿肌炎。产气荚膜梭菌是一种高致病性厌氧、形成芽孢的革兰氏阳性细菌,可引发黑腿病。黑腿病于1870年首次报道,但致病细菌直到1887年才被描述。产气荚膜梭菌存在于草地、淡水、青贮饲料、土壤以及健康动物的粪便中。已发现牛肠道和牧场土壤中均含有该细菌的芽孢,这表明感染是通过摄入芽孢而发生的。明显的病变在心脏中较少见,在骨骼肌中更常见。厌氧培养、聚合酶链反应、使用荧光抗体试验的免疫检测以及免疫组织化学是鉴定细菌的方法。动物组织中产生气体,即气肿肿胀,是黑腿病的一个标志。肿胀通常影响包括颈部、肩部、大腿和臀部在内的大肌肉。牛的黑腿病大多发生在一年中较温暖的月份,且该病通常呈季节性表现。对于没有死亡危险的感染动物,建议进行青霉素治疗并手术切除病变,包括筋膜切开术。疫苗接种是许多畜牧生产企业健康管理的关键部分,可预防黑腿病。可通过销毁尸体和焚烧表层土壤以根除任何残留的芽孢来控制黑腿病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed47/12451119/0ca8e107da69/OpenVetJ-15-6-2343-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed47/12451119/0ca8e107da69/OpenVetJ-15-6-2343-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed47/12451119/0ca8e107da69/OpenVetJ-15-6-2343-g001.jpg

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Blackleg: A deadly disease with a hidden cause.黑腿病:一种病因不明的致命疾病。
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本文引用的文献

1
Clostridial Infections in Cattle: A Comprehensive Review with Emphasis on Current Data Gaps in Brazil.牛的梭菌感染:一项全面综述,重点关注巴西当前的数据缺口
Animals (Basel). 2024 Oct 10;14(20):2919. doi: 10.3390/ani14202919.
2
Protection efficacy and immunogenicity of Clostridium chauvoei proteins as a subunit blackleg vaccine or an adjuvant for Clostridium perfringens epsilon toxoid.产气荚膜梭菌蛋白作为亚单位炭疽疫苗或产气荚膜梭菌 ε 型毒素佐剂的保护效力和免疫原性。
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The Chinese guideline for management of snakebites.
《中国蛇伤救治指南》
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Health Hazard Associated with the Presence of Bacteria in Food Products.食品中细菌存在所带来的健康危害。
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Production of highly soluble and immuno-reactive recombinant flagellin protein of Clostridium chauvoei.高产可溶性且免疫反应性强的魏氏梭菌 flagellin 重组蛋白的生产。
Anaerobe. 2024 Oct;89:102899. doi: 10.1016/j.anaerobe.2024.102899. Epub 2024 Aug 12.
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Comparative genome analyses of clinical and non-clinical strains.临床菌株与非临床菌株的比较基因组分析。
Front Microbiol. 2024 Jun 27;15:1404491. doi: 10.3389/fmicb.2024.1404491. eCollection 2024.
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Blackleg: A Review of the Agent and Management of the Disease in Brazil.黑腿病:巴西该病病原体及防治综述
Animals (Basel). 2024 Feb 16;14(4):638. doi: 10.3390/ani14040638.
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Coherent spore dispersion via drop-leaf interaction.通过落叶相互作用实现的相干孢子散布。
Sci Adv. 2024 Feb 2;10(5):eadj8092. doi: 10.1126/sciadv.adj8092. Epub 2024 Jan 31.
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Effect of formalin percentage, incubation time and temperature on Clostridium chauvoei culture inactivation and immunogenicity.福尔马林百分比、孵育时间和温度对产气荚膜梭菌培养物灭活及免疫原性的影响。
Anaerobe. 2023 Oct;83:102781. doi: 10.1016/j.anaerobe.2023.102781. Epub 2023 Sep 1.
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Improvement in the Surveillance System for Livestock Diseases and Antimicrobial Use Following Operational Research Studies in Sierra Leone January-March 2023.2023年1月至3月在塞拉利昂开展运筹学研究后,牲畜疾病和抗菌药物使用监测系统得到改进。
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