• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Linking SIRT1 Variants to Metabolic and Cardiovascular Phenotypes: Insights from Population Genetics and In Silico Structural Analysis.

作者信息

Grebenshchikov Eugene S, Pravednikova Anna E, Bezsonov Evgeny E, Kudryavtsev Denis S, Larina Svetlana N, Shidlovskii Yulii V

机构信息

Laboratory of Gene Expression Regulation in Development, Institute of Gene Biology RAS, Moscow, Russia.

Department of Biology and General Genetics, Federal State Autonomous Educational Instution of Нigher Education I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenovskiy University), Moscow, Russia.

出版信息

Cell Biochem Biophys. 2025 Sep 24. doi: 10.1007/s12013-025-01903-2.

DOI:10.1007/s12013-025-01903-2
PMID:40991201
Abstract
摘要

相似文献

1
Linking SIRT1 Variants to Metabolic and Cardiovascular Phenotypes: Insights from Population Genetics and In Silico Structural Analysis.将SIRT1基因变异与代谢和心血管表型联系起来：来自群体遗传学和计算机结构分析的见解
Cell Biochem Biophys. 2025 Sep 24. doi: 10.1007/s12013-025-01903-2.
2
Sirtuins, redox, and metabolic pathways in the brain of female PCOS mice.多囊卵巢综合征（PCOS）雌性小鼠大脑中的沉默调节蛋白、氧化还原和代谢途径
J Assist Reprod Genet. 2025 Jun 26. doi: 10.1007/s10815-025-03557-8.
3
SIRT1, resveratrol and aging.沉默调节蛋白1、白藜芦醇与衰老
Front Genet. 2024 May 9;15:1393181. doi: 10.3389/fgene.2024.1393181. eCollection 2024.
4
Unraveling the roles of mitochondrial sirtuins in aging-related diseases: From mechanistic insights to therapeutic strategies.解析线粒体去乙酰化酶在衰老相关疾病中的作用：从机制洞察到治疗策略
Metabolism. 2025 Nov;172:156356. doi: 10.1016/j.metabol.2025.156356. Epub 2025 Jul 24.
5
Uncoupling Proteins Variants Are Linked to Hypercholesterolemia and Abdominal Obesity in Metabolically Unhealthy Women.解偶联蛋白变体与代谢不健康女性的高胆固醇血症和腹部肥胖有关。
Lifestyle Genom. 2025;18(1):27-35. doi: 10.1159/000543484. Epub 2025 Jan 16.
6
Sirtuin 1 overexpression in mice preserves insulin and thermogenic responses in subcutaneous inguinal white adipose tissue under proinflammatory conditions.在促炎条件下，小鼠体内的沉默调节蛋白1过表达可维持皮下腹股沟白色脂肪组织中的胰岛素和产热反应。
J Physiol Biochem. 2025 Aug 4. doi: 10.1007/s13105-025-01109-3.
7
Impact of Resveratrol Supplementation on Human Sirtuin 1: A Grading of Recommendations Assessment, Development and Evaluation-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials.白藜芦醇补充剂对人体沉默信息调节因子1的影响：一项基于推荐分级评估、制定与评价的系统评价及随机对照试验的剂量反应荟萃分析
J Acad Nutr Diet. 2025 Mar 28. doi: 10.1016/j.jand.2025.03.011.
8
Clinical significance and prognostic value of SIRT1 genetic variants in sepsis: a multicenter hospital-based case-control study.脓毒症中SIRT1基因变异的临床意义及预后价值：一项基于多中心医院的病例对照研究。
Clin Epigenetics. 2025 Jul 30;17(1):135. doi: 10.1186/s13148-025-01944-7.
9
Common SIRT1 variants modify the effect of abdominal adipose tissue on aging-related lung function decline.常见的SIRT1基因变体可改变腹部脂肪组织对与衰老相关的肺功能下降的影响。
Age (Dordr). 2016 Jun;38(3):52. doi: 10.1007/s11357-016-9917-y. Epub 2016 Apr 28.
10
Inhibition of de novo ceramide synthesis by sirtuin-1 improves beta-cell function and glucose metabolism in type 2 diabetes.Sirtuin-1 通过抑制从头合成神经酰胺来改善 2 型糖尿病β细胞功能和葡萄糖代谢。
Cardiovasc Res. 2024 Sep 21;120(11):1265-1278. doi: 10.1093/cvr/cvae100.

本文引用的文献

1
Circadian disruption, clock genes, and metabolic health.昼夜节律紊乱、时钟基因与代谢健康。
J Clin Invest. 2024 Jul 15;134(14):e170998. doi: 10.1172/JCI170998.
2
Associations of metabolic disorders with hypertension and cardiovascular disease: recent findings and therapeutic perspectives.代谢紊乱与高血压和心血管疾病的关联：最新发现与治疗前景
Hypertens Res. 2024 Dec;47(12):3338-3344. doi: 10.1038/s41440-024-01737-0. Epub 2024 May 29.
3
AIUPred: combining energy estimation with deep learning for the enhanced prediction of protein disorder.
AIUPred：将能量估计与深度学习相结合，以增强对蛋白质无序性的预测。
Nucleic Acids Res. 2024 Jul 5;52(W1):W176-W181. doi: 10.1093/nar/gkae385.
4
NF-κB pathway as a molecular target for curcumin in diabetes mellitus treatment: Focusing on oxidative stress and inflammation.核因子κB信号通路作为姜黄素治疗糖尿病的分子靶点：聚焦于氧化应激与炎症
Cell Biochem Funct. 2024 Jun;42(4):e4030. doi: 10.1002/cbf.4030.
5
Sirtuins are Not Conserved Longevity Genes.沉默调节蛋白不是保守的长寿基因。
Life Metab. 2022 Oct;1(2):122-133. doi: 10.1093/lifemeta/loac025. Epub 2022 Sep 22.
6
SIRT7 in the aging process.SIRT7 在衰老过程中的作用。
Cell Mol Life Sci. 2022 May 18;79(6):297. doi: 10.1007/s00018-022-04342-x.
7
Association of Sirtuin 1 Gene Polymorphisms with the Risk of Coronary Heart Disease in Chinese Han Patients with Type 2 Diabetes Mellitus.Sirtuin 1 基因多态性与汉族 2 型糖尿病患者冠心病发病风险的关联。
J Diabetes Res. 2022 Apr 16;2022:8494502. doi: 10.1155/2022/8494502. eCollection 2022.
8
Regulation of SIRT1 and Its Roles in Inflammation.SIRT1 的调控及其在炎症中的作用。
Front Immunol. 2022 Mar 11;13:831168. doi: 10.3389/fimmu.2022.831168. eCollection 2022.
9
Diabetes Mellitus and the Heart.糖尿病与心脏
Exp Clin Endocrinol Diabetes. 2022 Sep;130(S 01):S123-S126. doi: 10.1055/a-1624-3593. Epub 2022 Mar 31.
10
Gene polymorphisms of SIRT1 in patients with rheumatoid arthritis.SIRT1 基因多态性与类风湿关节炎。
Int J Rheum Dis. 2022 Feb;25(2):210-217. doi: 10.1111/1756-185X.14257. Epub 2021 Dec 5.