大鼠冠状病毒（RCV）：一种在大鼠中普遍存在的、自然发生的嗜肺病毒。
Rat coronavirus (RCV): a prevalent, naturally occurring pneumotropic virus of rats.
作者信息
Parker J C, Cross S S, Rowe W P
出版信息
Arch Gesamte Virusforsch. 1970;31(3):293-302. doi: 10.1007/BF01253764.
Abstract
A new virus isolated from the lungs of rats is prevalent in colony reared and wild rats and induces a fatal pneumonitis in newborn rats. The virus, designated as rat coronavirus (RCV), exhibits properties representative of the coronavirus group: characteristic surface structure, particles somewhat variable in size averaging approximately 90 mμ, apparent RNA content, essential lipid, heat sensitivity, and a close serologie relationship with the mouse hepatitis virus complex. RCV grows well in primary rat kidney cell cultures, exhibits a pathognomonic type CPE, and produces a complement fixing antigen which is sensitive for detection of antibody and useful in sero-epidemiologic studies.
摘要
从大鼠肺部分离出的一种新病毒在饲养的鼠群和野生大鼠中普遍存在，并可在新生大鼠中引发致命性肺炎。这种病毒被命名为大鼠冠状病毒（RCV），具有冠状病毒属的典型特征：独特的表面结构、大小略有差异的颗粒（平均约90毫微米）、明显的RNA含量、必需脂质、热敏感性，以及与小鼠肝炎病毒复合体存在密切的血清学关系。RCV在原代大鼠肾细胞培养物中生长良好，呈现出特征性的C型细胞病变效应，并产生一种补体结合抗原，该抗原对抗体检测敏感，在血清流行病学研究中很有用。
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