冠状病毒之间的抗原关系。
Antigenic relationships amongst coronaviruses.
作者信息
Bradburne A F
出版信息
Arch Gesamte Virusforsch. 1970;31(3):352-64. doi: 10.1007/BF01253769.
Abstract
Several serological interrelationships between various members of the corona-virus group have been revealed in neutralization, complement fixation, and gel-diffusion tests, using human and hyperimmune animal sera. Several members of this group of human and animal pathogens are shown to cross-react in one or more type of test, but one member, avian infectious bronchitis virus, was shown to be unrelated. Mouse hepatitis virus (MHV) was found to be antigenically related to a number of human types of coronavirus. Difficulties were encountered in the investigation of paired human sera in demonstrating the specificity of antibody rises, placing doubt on the values of some serological studies. The significance of these interrelationships is discussed in the light of other investigations.
摘要
利用人和超免疫动物血清，在中和试验、补体结合试验和凝胶扩散试验中揭示了冠状病毒组各成员之间的几种血清学相互关系。这组人类和动物病原体的几个成员在一种或多种试验中显示出交叉反应，但其中一个成员，禽传染性支气管炎病毒，被证明没有关系。发现小鼠肝炎病毒（MHV）与多种人类冠状病毒在抗原上相关。在研究配对的人类血清以证明抗体升高的特异性时遇到了困难，这使人们对一些血清学研究的价值产生怀疑。结合其他研究讨论了这些相互关系的意义。
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